ArticleThe EMBO journal2003
A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 109 citations in OpenAlex.
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- Expression of the phagocytic receptors αFrontiers in immunology · 2022Article
- Ena/VASP proteins at the crossroads of actin nucleation pathways in dendritic cell migration.Frontiers in cell and developmental biology · 2022Article
- Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions.JCI insight · 2021Article
- BCL11B Regulates Arterial Stiffness and Related Target Organ Damage.Circulation research · 2021Article
- Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8.PLoS pathogens · 2020Article
- MASTL promotes cell contractility and motility through kinase-independent signaling.The Journal of cell biology · 2020Article
- Lamellipodin tunes cell migration by stabilizing protrusions and promoting adhesion formation.Journal of cell science · 2020Article
- Arginine inMolecular & cellular proteomics : MCP · 2020Article
- Review
- Actin cytoskeleton self-organization in single epithelial cells and fibroblasts under isotropic confinement.Journal of cell science · 2019Article
- The role of vasodilator-stimulated phosphoprotein (VASP) in the control of hepatic gluconeogenic gene expression.PloS one · 2019Article
- Article
- A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions.PloS one · 2018Article
- Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018Review
- MRL proteins cooperate with activated Ras in glia to drive distinct oncogenic outcomes.Oncogene · 2017Article
- Transcriptional responses to hyperplastic MRL signalling in Drosophila.Open biology · 2017Article
- Unravelling the Actin Cytoskeleton: A New Competitive Edge?Trends in cell biology · 2016Review
- Cell type-dependent mechanisms for formin-mediated assembly of filopodia.Molecular biology of the cell · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Vasodilator-stimulated phosphoprotein (VASP) is involved in multiple actin-mediated processes, including regulation of serum response factor (SRF) activity. We used the SRF transcriptional assay to define functional domains in VASP and to show that they coincide with those required for F-actin accumulation, as determined by a quantitative FACS assay. We identified inactive VASP mutants that can interfere both with F-actin assembly and with SRF activation by wild-type VASP. These VASP mutants also inhibit actin-based motility of Vaccinia virus and Shigella flexneri. VASP-induced F-actin accumulation and SRF activation require both functional Rho and its effector mDia, and conversely, mDia-mediated SRF activation is critically dependent on functional VASP. VASP and mDia also associate physically in vivo. These findings show that VASP and mDia function cooperatively downstream of Rho to control F-actin assembly and SRF activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.