ArticleThe EMBO journal2003
Drosophila polypyrimidine-tract binding protein (PTB) functions specifically in the male germline.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster.Molecular and cellular biology · 2019Article
- Satellite DNA-containing gigantic introns in a unique gene expression program during Drosophila spermatogenesis.PLoS genetics · 2019Article
- PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia.The Journal of reproduction and development · 2019Article
- Genome-wide identification of genes probably relevant to the adaptation of schizothoracins (Teleostei: Cypriniformes) to the uplift of the Qinghai-Tibet Plateau.BMC genomics · 2017Article
- Association between RNA-binding protein Ptbp2 and germ cell injury in an experimentally-induced unilateral cryptorchidism murine model.PloS one · 2017Article
- Article
- Drosophila polypyrimidine tract-binding protein (DmPTB) regulates dorso-ventral patterning genes in embryos.PloS one · 2014Article
- The splicing landscape is globally reprogrammed during male meiosis.Nucleic acids research · 2013Article
- Article
- Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo.PloS one · 2011Article
- Drosophila polypyrimidine tract-binding protein is necessary for spermatid individualization.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- hnRNP I is required to generate the Ca2+ signal that causes egg activation in zebrafish.Development (Cambridge, England) · 2009Article
- Early zebrafish development: it's in the maternal genes.Current opinion in genetics & development · 2009Article
- hnRNP I inhibits Notch signaling and regulates intestinal epithelial homeostasis in the zebrafish.PLoS genetics · 2009Article
- Determination of gene expression patterns using in situ hybridization to Drosophila testes.Nature protocols · 2009Article
- Genome-wide identification of alternatively spliced mRNA targets of specific RNA-binding proteins.PloS one · 2007Article
- Drosophila Sex-lethal protein mediates polyadenylation switching in the female germline.The EMBO journal · 2006Article
- Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translation.RNA (New York, N.Y.) · 2005Article
- PTB regulates the processing of a 3'-terminal exon by repressing both splicing and polyadenylation.Molecular and cellular biology · 2005Article
- Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase.Molecular and cellular biology · 2005Article
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Authors and funding
2 authors.
Funding
Abstract
The mammalian polypyrimidine-tract binding protein (PTB), which is a heterogeneous ribonucleoprotein, is ubiquitously expressed. Unexpectedly, we found that, in Drosophila melanogaster, the abundant PTB transcript is present only in males (third instar larval, pupal and adult stages) and in adult flies is restricted to the germline. Most importantly, a signal from the somatic sex-determination pathway that is dependent on the male-specific isoform of the doublesex protein (DSX(M)) regulates PTB, providing evidence for the necessity of soma-germline communication in the differentiation of the male germline. Analysis of a P-element insertion directly links PTB function with male fertility. Specifically, loss of dmPTB affects spermatid differentiation, resulting in the accumulation of cysts with elongated spermatids without producing fully separated motile sperms. This male-specific expression of PTB is conserved in D.virilis. Thus, PTB appears to be a particularly potent downstream target of the sex-determination pathway in the male germline, since it can regulate multiple mRNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.