ArticleVaccine2003
Oral immunization of cattle with hemagglutinin protein of rinderpest virus expressed in transgenic peanut induces specific immune responses.
Article in Vaccine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Exploring recent progress of molecular farming for therapeutic and recombinant molecules in plant systems.Heliyon · 2024Review
- Compendium on Food Crop Plants as a Platform for Pharmaceutical Protein Production.International journal of molecular sciences · 2022Review
- Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production.Plants (Basel, Switzerland) · 2020Review
- A Preliminary Study of a Lettuce-Based Edible Vaccine Expressing the Cysteine Proteinase ofFrontiers in immunology · 2018Article
- Advances in peste des petits ruminants vaccines.Veterinary microbiology · 2017Review
- Immune response of rats vaccinated orally with various plant-expressed recombinant cysteine proteinase constructs when challenged with Fasciola hepatica metacercariae.PLoS neglected tropical diseases · 2017Article
- Recombinant Plant Engineering for Immunotherapeutic Production.Current molecular biology reports · 2017Review
- Plant-based vaccines for animals and humans: recent advances in technology and clinical trials.Therapeutic advances in vaccines · 2015Review
- Plant-based solutions for veterinary immunotherapeutics and prophylactics.Veterinary research · 2014Review
- The effect of plant tissue and vaccine formulation on the oral immunogenicity of a model plant-made antigen in sheep.PloS one · 2012Article
- Cross-reactivity of anti-Eimeria tenella antibody fragments on merozoites and sporozoites of different chicken Eimeria species.Parasitology research · 2011Article
- Expression and immunogenicity of the mycobacterial Ag85B/ESAT-6 antigens produced in transgenic plants by elastin-like peptide fusion strategy.Journal of biomedicine & biotechnology · 2010Article
- Plant production of veterinary vaccines and therapeutics.Current topics in microbiology and immunology · 2009Review
- Transgenic plants for animal health: plant-made vaccine antigens for animal infectious disease control.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2008Article
- Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview.Transgenic research · 2007Review
- High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice.Journal of biotechnology · 2005Article
- Generation of the transgenic potato expressing full-length spike protein of infectious bronchitis virus.Journal of biotechnology · 2004Article
- Plants as bioreactors for the production of vaccine antigens.Biotechnology advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rinderpest is an acute, highly contagious often fatal disease of large and small ruminants, both domestic and wild. Global eradication of rinderpest needs a robust, safe and cost-effective vaccine. The causative agent, rinderpest virus (RPV) is an important member of the genus Morbillivirus in the Paramyxoviridae family. We have generated transgenic peanut (Arachis hypogea L.) plants expressing hemagglutinin protein of RPV and report here, the induction of immune responses in cattle following oral feeding with transgenic leaves expressing hemagglutinin protein without oral adjuvant. Hemagglutinin-specific antibody was detected in the serum as confirmed by immunohistochemical staining of virus-infected cells, and in vitro neutralization of virus infectivity. Oral delivery also resulted in cell-mediated immune responses.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.