SynthesisThe Cochrane database of systematic reviews2003
Gastro-oesophageal reflux treatment for asthma in adults and children.
Synthesis in The Cochrane database of systematic reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Pharmacological and surgical interventions for the treatment of gastro-oesophageal reflux in adults and children with asthma.The Cochrane database of systematic reviews · 2021Pooled it
- Canadian Thoracic Society Asthma Management Continuum--2010 Consensus Summary for children six years of age and over, and adults.Canadian respiratory journalGuideline
- Effects of asymptomatic proximal and distal gastroesophageal reflux on asthma severity.American journal of respiratory and critical care medicine · 2009Trial
- Efficacy of esomeprazole for treatment of poorly controlled asthma.The New England journal of medicine · 2009Trial
- Acid suppression does not change respiratory symptoms in children with asthma and gastro-oesophageal reflux disease.Archives of disease in childhood · 2005Trial
- Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases.Communications biology · 2024Article
- Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD.The journal of allergy and clinical immunology. In practice · 2021Review
- 2021 Brazilian Thoracic Association recommendations for the management of severe asthma.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2021Review
- Gastroesophageal Reflux Disease: A General Overview.HCA healthcare journal of medicine · 2020Review
- The Effects of Obesity in Asthma.Current allergy and asthma reports · 2019Review
- Asthma in the Primary Care Setting.The Medical clinics of North America · 2019Review
- Severe Asthma-Perspectives From Adult and Pediatric Pulmonology.Frontiers in pediatrics · 2019Review
- Aspiration Risk and Respiratory Complications in Patients with Esophageal Atresia.Frontiers in pediatrics · 2017Review
- Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil.Clinical and translational allergy · 2017Article
- Fewer acute respiratory infection episodes among patients receiving treatment for gastroesophageal reflux disease.PloS one · 2017Article
- Clinically relevant subgroups in COPD and asthma.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Control of asthma in real life: still a valuable goal?European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Advances in the evaluation and management of esophageal disease of systemic sclerosis.Current rheumatology reports · 2015Review
- Coexisting chronic conditions associated with mortality and morbidity in adult patients with asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2014Article
Corrections and comments
- Updated by
- Update of
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma and gastro-oesophageal reflux are both common medical conditions and often co-exist. Studies have shown conflicting results concerning the effects of lower oesophageal acidification as a trigger of asthma. Furthermore, asthma might precipitate gastro-oesophageal reflux. Thus a temporal association between the two does not establish that gastro-oesophageal reflux triggers asthma. Randomised trials of a number of treatments for gastro-oesophageal reflux in asthma have been conducted to determine whether treatment of reflux improves asthma.
objectivesThe objective of this review was to evaluate the effectiveness of treatments for gastro-oesophageal reflux in terms of their benefit on asthma. SEARCH STRATEGY: The Cochrane Airways Group trials register, review articles and reference lists of articles were searched. SELECTION CRITERIA: Randomised controlled trials of treatment for oesophageal reflux in adults and children with a diagnosis of both asthma and gastro-oesophageal reflux. DATA COLLECTION AND ANALYSIS: Trial quality and data extraction were carried out by two independent reviewers. Authors were contacted for confirmation or more data. MAIN
resultsTwelve trials met the inclusion criteria. Interventions included proton pump inhibitors (n=6), histamine antagonists (n=5), surgery (n=1) and conservative management (n=1). Treatment duration ranged from 1 week to 6 months. A temporal association between asthma and gastro-oesophageal reflux was investigated in 4 trials and found to be present in a proportion of participants in these trials. Anti-reflux treatment did not consistently improve lung function, asthma symptoms, nocturnal asthma or the use of asthma medications. REVIEWER'S
conclusionsIn asthmatic subjects with gastro-oesophageal reflux, (but who were not recruited specifically on the basis of reflux-associated respiratory symptoms), there was no overall improvement in asthma following treatment for gastro-oesophageal reflux. Subgroups of patients may gain benefit, but it appears difficult to predict responders.
Indexed as
Identifiers
12804410What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.