SynthesisAmerican journal of human genetics2003
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.
Synthesis in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 5 of them syntheses that pooled it.
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Who cites it
120 citing papers in PubMed, 5 syntheses or guidelines pooled it, 571 citations in OpenAlex.
- Population-based linkage analysis of schizophrenia and bipolar case-control cohorts identifies a potential susceptibility locus on 19q13.Molecular psychiatry · 2010Pooled it
- Heterogeneity-based genome search meta-analysis for preeclampsia.Human genetics · 2006Pooled it
- Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis.Human genetics · 2005Pooled it
- Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis.Molecular psychiatry · 2005Pooled it
- Meta-analysis in psychiatric genetics.Current psychiatry reports · 2005Pooled it
- Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families.Molecular psychiatry · 2005Trial
- A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.Molecular psychiatry · 2004Trial
- Article
- Mapping the expression of an ANK3 isoform associated with bipolar disorder in the human brain.Translational psychiatry · 2022Article
- Genetic polymorphisms of PIP5K2A and course of schizophrenia.BMC medical genetics · 2020Article
- On the diagnostic and neurobiological origins of bipolar disorder.Translational psychiatry · 2020Review
- NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly.American journal of human genetics · 2018Article
- Expressional profile of the diacylglycerol kinase eta gene DGKH.European archives of psychiatry and clinical neuroscience · 2017Article
- Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder.Psychiatric genetics · 2017Article
- A pilot study on commonality and specificity of copy number variants in schizophrenia and bipolar disorder.Translational psychiatry · 2016Article
- Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder.Translational psychiatry · 2016Article
- Evaluation of potential novel variations and their interactions related to bipolar disorders: analysis of genome-wide association study data.Neuropsychiatric disease and treatment · 2016Article
- Evidence for the role of corticotropin-releasing factor in major depressive disorder.Neuroscience and biobehavioral reviews · 2015Review
- A composite peripheral blood gene expression measure as a potential diagnostic biomarker in bipolar disorder.Translational psychiatry · 2015Article
- MIR137 variants identified in psychiatric patients affect synaptogenesis and neuronal transmission gene sets.Molecular psychiatry · 2015Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
78 authors at 20 institutions in 14 countries.
Funding
Abstract
Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions with significant support for linkage in the combined data. The two primary analyses considered available linkage data for "very narrow" (i.e., BP-I and schizoaffective disorder-BP) and "narrow" (i.e., adding BP-II disorder) disease models, with the ranks weighted for sample size. A "broad" model (i.e., adding recurrent major depression) and unweighted analyses were also performed. No region achieved genomewide statistical significance by several simulation-based criteria. The most significant P values (<.01) were observed on chromosomes 9p22.3-21.1 (very narrow), 10q11.21-22.1 (very narrow), and 14q24.1-32.12 (narrow). Nominally significant P values were observed in adjacent bins on chromosomes 9p and 18p-q, across all three disease models on chromosomes 14q and 18p-q, and across two models on chromosome 8q. Relatively few BPD pedigrees have been studied under narrow disease models relative to the schizophrenia GSMA data set, which produced more significant results. There was no overlap of the highest-ranked regions for the two disorders. The present results for the very narrow model are promising but suggest that more and larger data sets are needed. Alternatively, linkage might be detected in certain populations or subsets of pedigrees. The narrow and broad data sets had considerable power, according to simulation studies, but did not produce more highly significant evidence for linkage. We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region.
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