ArticleDiabetologia2003
Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells.
Article in Diabetologia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Stem Cell Therapy for the Management of Type 1 Diabetes: Advances and Perspectives.Endocrine, metabolic & immune disorders drug targets · 2024Review
- A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome.Biomedicines · 2023Review
- Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges.Stem cell research & therapy · 2022Review
- Signaling Molecules Regulating Pancreatic Endocrine Development from Pluripotent Stem Cell Differentiation.International journal of molecular sciences · 2020Review
- Signals in the pancreatic islet microenvironment influence β-cell proliferation.Diabetes, obesity & metabolism · 2017Review
- Human fetal liver stromal cell co-culture enhances the differentiation of pancreatic progenitor cells into islet-like cell clusters.Stem cell reviews and reports · 2014Article
- Fetal pancreas as a source for islet transplantation: sweet promise and current challenges.Diabetes · 2013Article
- The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells.PloS one · 2012Article
- Embryonic stem cell transplantation correlates with endogenous neurogenin 3 expression and pancreas regeneration in streptozotocin-injured mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Activin A-induced differentiation of embryonic stem cells into endoderm and pancreatic progenitors-the influence of differentiation factors and culture conditions.Stem cell reviews and reports · 2009Review
- Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.PloS one · 2009Article
- Pancreatic endocrine and exocrine cell ontogeny from renal capsule transplanted embryonic stem cells in streptozocin-injured mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer.The American journal of pathology · 2007Article
- Growing organs for transplantation from embryonic precursor tissues.Immunologic research · 2007Article
- Role of FGF1, FGF2 and FGF7 in the development of the pancreas from control and streptozotocin-treated hamsters.Cell proliferation · 2006Article
- Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans.Diabetologia · 2006Article
- Embryonic pig pancreatic tissue transplantation for the treatment of diabetes.PLoS medicine · 2006Article
- Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells.Diabetologia · 2005Article
- Proteomic Profiling Reveals the Ambivalent Character of the Mesenchymal Stem Cell Secretome: Assessing the Effect of Preconditioned Media on Isolated Human Islets.Cell transplantationArticle
- Identification and expansion of pancreatic stem/progenitor cells.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims and hypothesisKeratinocyte growth factor (KGF) is a member of the heparin-binding fibroblast growth factor family with a high degree of specificity for epithelial cells in vitro and in vivo. Our aim was to study the effect of KGF on beta-cell growth and differentiation on islet-like cell clusters derived from human fetal pancreas.
methodsWe investigated the effects of KGF, in vitro, on beta-cell differentiation from undifferentiated pancreatic precursor cells and in vivo after transplantating human fetal pancreatic cells into athymic rats treated with KGF.
resultsTreatment of islet-like cell clusters with KGF in vitro did not change the number of insulin producing cells, as measured by the measurement of insulin content or DNA. The in vivo treatment of recipient rats with KGF increased the number of beta cells within the grafts 8 weeks after transplantation. At this time, glucose-stimulated insulin secretion was evaluated by glucose stimulation tests in rats bearing the transplants. Measurements of human C-peptide concentrations after glucose challenge showed that the newly differentiated beta cells in the KGF-treated group were functionally competent as opposed to the control group, where the graft failed to release insulin appropriately. CONCLUSION/
interpretationThese findings suggest that in vivo, KGF is capable of inducing human fetal beta-cell expansion. The growth promoting effect of KGF on beta cells occurred mainly through the activation of ductal cell proliferation and their subsequent differentiation into beta cells.
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