ArticleDiabetologia2003
Atopic eczema in early childhood could be protective against Type 1 diabetes.
Article in Diabetologia, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Is Atopic Dermatitis Associated with Systemic Metabolic Disturbances? A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Type 1 diabetes and asthma: a systematic review and meta-analysis of observational studies.Endocrine · 2022Pooled it
- Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes.BMC medical genomics · 2023Article
- Allergy and autoimmunity in children: non-mutually exclusive diseases. A narrative review.Frontiers in pediatrics · 2023Review
- Involvement of Atopic Dermatitis in the Development of Systemic Inflammatory Diseases.International journal of molecular sciences · 2022Review
- Article
- [Atopic dermatitis and general medical comorbidities].Der Internist · 2019Review
- Association of atopic dermatitis with allergic, autoimmune, and cardiovascular comorbidities in US adults.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- No association between loss-of-function mutations in filaggrin and diabetes, cardiovascular disease, and all-cause mortality.PloS one · 2013Article
- A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study.BMJ open · 2011Article
- Frequency of atopy and allergic disorders among adults with Type 1 diabetes mellitus in the southern Marmara region of Turkey.Journal of endocrinological investigation · 2008Article
- Combinations of common chronic paediatric diseases deviate the immune response in diverging directions.Clinical and experimental immunology · 2006Article
- Inverse relationship between allergic contact dermatitis and type 1 diabetes mellitus: a retrospective clinic-based study.Diabetologia · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisAccording to the Th1/Th2 paradigm Type 1 diabetes and atopic diseases are assumed to be mutually exclusive on the individual level. We analysed the association between Type 1 diabetes and atopic diseases in a case-control design in order to test the hypothesis that atopic diseases in early childhood could protect against Type 1 diabetes.
methodsWe carried out a nationwide population-based case-control study enrolling 760 cases newly-diagnosed with Type 1 diabetes under five years of age between July 1992 and December 1995 and 1871 controls randomly selected from the general population and individually matched on sex, age and place of residence. Information on atopic diseases was obtained by a mailed parent-administered questionnaire. Data were analysed by multivariate logistic regression adjusting for potential confounders (family history of diabetes, social status, duration of overall breast feeding, number of children in family, maternal age at delivery).
resultsAtopic eczema was less frequent in diabetic (13.3%) than in non-diabetic children (18.0%) and was significantly associated with a reduced risk of Type 1 diabetes. The adjusted odds ratio was 0.71 (95% CI 0.53-0.96). Hay fever and asthma were not significantly associated with diabetes risk (OR 0.98 (95% CI 0.47-2.01) and 1.46 (95% CI 0.70-3.06), respectively). CONCLUSION/
interpretationIn this large population-based case-control study in pre-school children an inverse association was observed between atopic eczema and Type 1 diabetes. Thus, in accordance with the Th1/Th2 paradigm development of atopic eczema in early childhood could be protective against childhood Type 1 diabetes.
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