ArticleProceedings of the National Academy of Sciences of the United States of America2003
A multistep mechanism for the activation of rearrangement in the immune system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- The pioneering work of Howard Cedar and his team in unraveling the roles DNA methylation plays in regulating genome function.Frontiers in epigenetics and epigenomics · 2026Article
- MicroRNA-376b-3p targets RGS1 mRNA to inhibit proliferation, metastasis, and apoptosis in osteosarcoma.Annals of translational medicine · 2021Article
- RAG enhances BCR-ABL1-positive leukemic cell growth through its endonuclease activity in vitro and in vivo.Cancer science · 2021Article
- Asynchronous Replication Timing: A Mechanism for Monoallelic Choice During Development.Frontiers in cell and developmental biology · 2021Review
- Epigenetic regulation of monoallelic rearrangement (allelic exclusion) of antigen receptor genes.Frontiers in immunology · 2014Review
- Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.Molecular immunology · 2007Article
- Fine tuning of globin gene expression by DNA methylation.PloS one · 2006Article
- B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.Nature immunology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rearrangement of immune receptor loci is a developmentally controlled process that takes place exclusively in lymphoid cells. We have used a stable transfection system in pre-B cells to show that DNA methylation brings about histone underacetylation, histone H3(K9) methylation, DNaseI resistance, and strong inhibition of both transcription and recombination. Strikingly, this repression is maintained in dividing cells even after removal of the original methyl groups responsible for its establishment, but in this state, rearrangement can now be induced by reacetylation of local histones using the drug Trichostatin A. This same combination of demethylation and histone acetylation is also required to activate germline transcription and recombination from the endogenous kappa locus in vivo. These results indicate that the regulation of rearrangement is carried out by a multilayered synergistic process.
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Registered trials
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