ArticleProceedings of the National Academy of Sciences of the United States of America2003
Impairment of reward-related learning by cholinergic cell ablation in the striatum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 114 citations in OpenAlex.
- A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependence.Biological psychiatry · 2008Trial
- Traumatic brain injury exacerbates alcohol consumption and neuroinflammation with decline in cognition and cholinergic activity.Translational psychiatry · 2025Article
- The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice.Nature communications · 2024Article
- Article
- Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice.bioRxiv : the preprint server for biology · 2023Article
- A synaptomic analysis reveals dopamine hub synapses in the mouse striatum.Nature communications · 2022Article
- Cholinergic regulation of object recognition memory.Frontiers in behavioral neuroscience · 2022Review
- Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory.Scientific reports · 2021Article
- Article
- Place vs. Response Learning: History, Controversy, and Neurobiology.Frontiers in behavioral neuroscience · 2020Article
- Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2.Frontiers in neural circuits · 2018Review
- α6β2 subunit containing nicotinic acetylcholine receptors exert opposing actions on rapid dopamine signaling in the nucleus accumbens of rats with high-versus low-response to novelty.Neuropharmacology · 2017Article
- The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens.Molecular psychiatry · 2015Article
- Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions.Annals of the New York Academy of Sciences · 2015Review
- Molecular imaging of levodopa-induced dyskinesias.Cellular and molecular life sciences : CMLS · 2015Review
- Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Differential effects of systemic cholinergic receptor blockade on Pavlovian incentive motivation and goal-directed action selection.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Forebrain deletion of the vesicular acetylcholine transporter results in deficits in executive function, metabolic, and RNA splicing abnormalities in the prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior.Nature communications · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The striatum in the basal ganglia-thalamocortical circuitry is a key neural substrate that is implicated in motor balance and procedural learning. The projection neurons in the striatum are dynamically modulated by nigrostriatal dopaminergic input and intrastriatal cholinergic input. The role of intrastriatal acetylcholine (ACh) in learning behaviors, however, remains to be fully clarified. In this investigation, we examine the involvement of intrastriatal ACh in different categories of learning by selectively ablating the striatal cholinergic neurons with use of immunotoxin-mediated cell targeting. We show that selective ablation of cholinergic neurons in the striatum impairs procedural learning in the tone-cued T-maze memory task. Spatial delayed alternation in the T-maze learning test is also impaired by cholinergic cell elimination. In contrast, the deficit in striatal ACh transmission has no effect on motor learning in the rota-rod test or spatial learning in the Morris water-maze test or on contextual- and tone-cued conditioning fear responses. We also report that cholinergic cell elimination adaptively up-regulates nicotinic ACh receptors not only within the striatum but also in the cerebral cortex and substantia nigra. The present investigation indicates that cholinergic modulation in the local striatal circuit plays a pivotal role in regulation of neural circuitry involving reward-related procedural learning and working memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.