ArticleProceedings of the National Academy of Sciences of the United States of America2003
Direct molecular haplotyping of long-range genomic DNA with M1-PCR.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Investigation of the DAOA/G30 locus in panic disorder.Molecular psychiatry · 2005Trial
- Oligonucleotide hybridization with magnetic separation assay for multiple SNP phasing.Analytica chimica acta: X · 2020Article
- Enhancement of the polymerase chain reaction by tungsten disulfide.RSC advances · 2019Article
- Dominant Allele Phylogeny and Constitutive Subgenome Haplotype Inference in Bananas Using Mitochondrial and Nuclear Markers.Genome biology and evolution · 2017Article
- Chromosome-Range Whole-Genome High-Throughput Experimental Haplotyping by Single-Chromosome Microdissection.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Association of fatty-acid synthase polymorphisms and expression with outcomes after radical prostatectomy.Prostate cancer and prostatic diseases · 2015Article
- A rapid molecular approach for chromosomal phasing.PloS one · 2015Article
- Whole-genome haplotyping by dilution, amplification, and sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Multiplex protein detection with DNA readout via mass spectrometry.New biotechnology · 2013Article
- Massively parallel haplotyping on microscopic beads for the high-throughput phase analysis of single molecules.PloS one · 2012Article
- Enhanced Specificity of Multiplex Polymerase Chain Reaction via CdTe Quantum Dots.Nanoscale research letters · 2011Article
- Whole-genome molecular haplotyping of single cells.Nature biotechnology · 2011Article
- Experimental generation of SNP haplotype signatures in patients with sickle cell anaemia.PloS one · 2010Article
- Shape-IT: new rapid and accurate algorithm for haplotype inference.BMC bioinformatics · 2008Article
- Inference of haplotypic phase and missing genotypes in polyploid organisms and variable copy number genomic regions.BMC bioinformatics · 2008Article
- Digital PCR for the molecular detection of fetal chromosomal aneuploidy.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Automated comparative sequence analysis by base-specific cleavage and mass spectrometry for nucleic acid-based microbial typing.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- ISHAPE: new rapid and accurate software for haplotyping.BMC bioinformatics · 2007Article
- An efficient method for multi-locus molecular haplotyping.Nucleic acids research · 2007Article
- MHC haplotype matching for unrelated hematopoietic cell transplantation.PLoS medicine · 2007Article
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2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Haplotypes, combinations of several phase-determined polymorphic markers, are extremely valuable for studies of disease association and chromosome evolution. Here we describe a technique called M1-PCR (M for "multiplex" and 1 for "single-copy DNA molecules") that enables direct molecular haplotyping of several polymorphic markers separated by as many as 24 kb. A genomic DNA sample first is diluted to approximately single-copy. The haplotype is directly determined by simultaneously genotyping several polymorphic markers in the same reaction with a multiplex PCR and base extension reaction. This approach does not rely on pedigree data and does not require previous amplification of the entire genomic region containing the selected markers.
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