ArticleGut2003
Ten year incidence of HCV infection in northern Italy and frequency of spontaneous viral clearance.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Pooled it
- Risk of window period hepatitis-C infection in high infectious risk donors: systematic review and meta-analysis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2011Pooled it
- Chronic Hepatitis C Virus Infection: An Ongoing Challenge in Screening and Treatment.Life (Basel, Switzerland) · 2023Review
- Complications and Challenges in the Management of Iraqi Patients with β-Thalassemia Major: A Single-center Experience.Oman medical journal · 2020Article
- Incidence and Risk Factors for Hepatitis C Virus Infection among Illicit Drug Users in Italy.Journal of urban health : bulletin of the New York Academy of Medicine · 2018Article
- High seroprevalence of HCV in the Abruzzo Region, Italy: results on a large sample from opt-out pre-surgical screening.Infection · 2016Article
- The evolving incidence of hepatitis C virus infection in Italy.Hepatitis monthly · 2012Article
- The impact of illicit drug use on spontaneous hepatitis C clearance: experience from a large cohort population study.PloS one · 2011Article
- Predictive factors for response to peginterferon-alpha and ribavirin treatment of chronic HCV infection in patients aged 65 years and more.Digestive diseases and sciences · 2010Article
- Prospective follow-up of patients with acute hepatitis C virus infection in Brazil.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2010Article
- Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2010Article
- Hepatitis C in the elderly: epidemiology, natural history, and treatment.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2009Review
- Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2008Article
- Hepatocellular carcinoma prevention: a worldwide emergence between the opulence of developed countries and the economic constraints of developing nations.World journal of gastroenterology · 2006Review
- Correlates of HCV seropositivity among familial contacts of HCV positive patients.BMC public health · 2006Article
- HBV, HCV, and TTV detection by in situ polymerase chain reaction could reveal occult infection in hepatocellular carcinoma: comparison with blood markers.Journal of clinical pathology · 2006Article
- Interferon-gamma is produced by CD8 T cells in response to HLA-A24-restricted hepatitis C virus epitopes after sustained virus loss.Clinical and experimental immunology · 2005Article
- Article
- New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0.World journal of gastroenterology · 2005Article
- Prospective study in 142 cases of hepatitis C virus infection.World journal of gastroenterology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known of the incidence of hepatitis C virus (HCV) infection, and the frequency of spontaneous viral clearance in the general population is unknown. We conducted an epidemiological study in two Apennine towns in northern Italy.
methodsAnti-HCV (ELISA and RIBA third generation) and HCV-RNA by polymerase chain reaction were tested in thawed sera from an adult general population of Loiano-Monghidoro in 1986 and 1996, obtained in the context of the MICOL (Multicenter Italian Study on Cholelithiasis). In 1999, anti-HCV positive subjects and sex and age matched controls were recalled in order to identify risk factors for acquiring HCV infection and to assess the family composition of anti-HCV+ subjects.
resultsFor 1646 subjects, sera were available from both 1986 and 1996 (mean age in 1986 43 (0.39) years). In 1986, 57 (3.46%) subjects were HCV antibody positive (HCV-Ab+). Eight new cases were recorded in 1996: adult incidence was 50.3 cases/100 000 inhabitants/year. Fifty three of 63 (84.1%) HCV-Ab+ sera were also HCV-RNA+. Genotype 2a/2c accounted for 44% and 1b for 47.0% of cases. HCV-Ab+ subjects had higher serum levels of alanine aminotransferase with respect to controls (p<0.005), as did subjects infected with genotype 1 with respect to those with genotype 2 (p<0.05). Eleven of 65 (16.9%) HCV-Ab+ subjects spontaneously cleared HCV-Ab; 7/11 also lost HCV-RNA- in both serum and leucocytes. Sixteen anti-HCV+ subjects belonged to families containing more than one infected member. Married couples accounted for 10 of these 16 subjects. In four of these five married couples, HCV genotype was identical in the two spouses.
conclusionsIn rural northern Italy, the adult incidence of HCV is approximately 50 cases/100 000 inhabitants/year. Our findings suggest that as many as 17% of infected subjects may spontaneously clear HCV-Ab. Interfamilial transmission seems to have a role in the spread of infection.
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