ArticleGut2003
Duodenal expression of iron transport molecules in untreated haemochromatosis subjects.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Distinct roles of ferric carboxymaltose and ferric derisomaltose on phosphate homeostasis in iron deficiency anemia.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2025Article
- The Roles of DMT1 in Inflammatory and Degenerative Diseases.Molecular neurobiology · 2025Review
- The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation.International journal of molecular sciences · 2022Review
- Article
- Article
- Article
- Iron uptake and transport across physiological barriers.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2016Review
- Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure.Metallomics : integrated biometal science · 2016Article
- Review
- Relationship of Baseline Hemoglobin Level with Serum Ferritin, Postphlebotomy Hemoglobin Changes, and Phlebotomy Requirements among HFE C282Y Homozygotes.BioMed research international · 2015Article
- Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease.Journal of cellular and molecular medicine · 2014Article
- Changes in iron transporter divalent metal transporter 1 in proximal jejunum after gastric bypass.World journal of gastroenterology · 2014Article
- Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency.Journal of cellular and molecular medicine · 2012Article
- Relationship between gene expression of duodenal iron transporters and iron stores in hemochromatosis subjects.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Interrelationships between circulating gastrin and iron status in mice and humans.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- The relevance of the intestinal crypt and enterocyte in regulating iron absorption.Pflugers Archiv : European journal of physiology · 2007Review
- Proton pump inhibitors suppress absorption of dietary non-haem iron in hereditary haemochromatosis.Gut · 2007Article
- Differential expression of genes related to HFE and iron status in mouse duodenal epithelium.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Normal iron metabolism and the pathophysiology of iron overload disorders.The Clinical biochemist. Reviews · 2006Article
- Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsIn HFE associated hereditary haemochromatosis, the duodenal enterocyte behaves as if iron deficient and previous reports have shown increased duodenal expression of divalent metal transporter 1 (DMT1) and iron regulated gene 1 (Ireg1) in affected subjects. In those studies, many patients had undergone venesection, which is a potent stimulus of iron absorption. Our study investigated duodenal expression of DMT1 (IRE and non-IRE), Ireg1, hephaestin, and duodenal cytochrome-b (Dyctb) in untreated C282Y homozygous haemochromatosis patients, iron deficient patients, and iron replete subjects.
methodsTotal RNA was extracted from duodenal biopsies and expression of the iron transport genes was assessed by ribonuclease protection assay.
resultsExpression of DMT1 (IRE) and Ireg1 was increased 3-5-fold in iron deficient subjects compared with iron replete subjects. Duodenal expression of DMT1 (IRE) and Ireg1 was similar in haemochromatosis patients and iron replete subjects but in haemochromatosis patients with elevated serum ferritin concentrations, both DMT1 (IRE) and Ireg1 expression were inappropriately increased relative to serum ferritin concentration. Hephaestin and Dcytb levels were not upregulated in haemochromatosis. DMT1 (IRE) and Ireg1 levels showed significant inverse correlations with serum ferritin concentration in each group of patients.
conclusionsThese findings are consistent with DMT1 (IRE) and Ireg1 playing primary roles in the adaptive response to iron deficiency. Untreated haemochromatosis patients showed inappropriate increases in DMT1 (IRE) and Ireg1 expression for a given level of serum ferritin concentration, although the actual level of expression of these iron transport genes was not significantly different from that of normal subjects.
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