ArticleEuropean journal of epidemiology2003
Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene.
Article in European journal of epidemiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- IGF-I (CA) repeat polymorphisms and risk of cancer: a meta-analysis.Journal of human genetics · 2008Pooled it
- A microsatellite polymorphism in IGF1 gene promoter and timing of natural menopause in Caucasian women.International journal of medical sciences · 2015Article
- The Association between IGF-1 Polymorphisms, IGF-1 Serum Levels, and Cognitive Functions in Healthy Adults: The Amsterdam Growth and Health Longitudinal Study.International journal of endocrinology · 2014Article
- Does insulin-like growth factor 1 genotype influence muscle power response to strength training in older men and women?European journal of applied physiology · 2012Article
- IGF gene polymorphisms and breast cancer in African-American and Hispanic women.International journal of oncology · 2011Article
- Influence of promoter region variants of insulin-like growth factor pathway genes on the strength-training response of muscle phenotypes in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2007Article
- Lack of association between genetic polymorphisms in IGF1 and IGFBP3 with twin births in a Brazilian population (Cândido Godói, Rio Grande do Sul).Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Polymorphic microsatellite dinucleotide (cytosine-adenine, CA) repeats of the insulin-like growth factor-I (IGF-I) gene may have implications in the development of certain types of cancer and osteoporosis. We studied correlations between IGF-I genotypes determined by direct sequencing and plasma IGF-I levels among 113 healthy individuals (60 men and 53 women), who were originally enrolled as controls for hospital-based case-control studies of breast and prostate cancer. On the contrary to an earlier observation, there were no differences in plasma IGF-I levels between those with and without the allele of 19 repeats. With adjustment for other confounders, there were no trends in plasma IGF-I levels with increasing or decreasing the number of CA repeats among all study subjects combined, all Whites or all Blacks, suggesting no overall functional significance of this polymorphism. Opposite trends observed in gender and racial subgroups, i.e., an inverse association between plasma IGF-I levels and the CA repeat length in white women and a positive association in black men, are likely to be chance findings.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.