Evidence map›Paper›PMID 12800493›Full record

ReviewFolia microbiologica2003

Mammalian antibiotic peptides.

P Síma, I Trebichavský, K Sigler

Abstract readReview
PubMed Publisher
In one paragraph

Review in Folia microbiologica, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

P SímaDivision of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague, Czechia. sima@biomed.cas.cz
I Trebichavský
K Sigler
Czech Academy of Sciences · CZCzech Academy of Sciences, Institute of Microbiology · CZInstitute of Microbiology · BY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing development of bacterial resistance to traditional antibiotics has reached alarming levels, thus creating a strong need to develop new antimicrobial agents. These new antibiotics should possess novel mechanisms of action and different cellular targets compared with existing antimicrobials. Recent discoveries and isolations of so-called animal antibiotics, mostly small cationic peptides, which represent a potent branch of natural immunity, offered the possibility to acquire new and effective antibiotics of this provenance. To this date, more than 500 antibiotic peptides have been distinguished and defined. Their antimicrobial properties present new opportunities for their use as antibiotics or for construction of their more effective derivatives, but much research is still required to pave the way to their practical use. This is a survey of substances forming an armamentarium of natural immunity of mammals.

Indexed as

Immunity, InnatePeptidesAnimalsAnti-Bacterial AgentsBacteriaBacterial InfectionsBlood PlateletsEosinophilsHumansMacrophagesNeutrophilsAnti-Bacterial AgentsPeptides

Identifiers

PMID12800493
OpenAlexW3100919880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.