Evidence map›Paper›PMID 12800239›Full record

ArticleWorld journal of gastroenterology2003

Expression and cell-specific localization of cholecystokinin receptors in rat lung.

Bin Cong, Shu-Jin Li, Yi-Ling Ling, Yu-Xia Yao, Zhen-Yong Gu, Jun-Xia Wang, Hong-Yu You

Open access · bronzeAbstract read
In one paragraph

Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bin CongDepartment of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China.
Shu-Jin Li
Yi-Ling Ling
Yu-Xia Yao
Zhen-Yong Gu
Jun-Xia Wang
Hong-Yu You
Hebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo elucidate whether CCK receptors exist in lung tissues and their precise cellular localization in the lung.

methodsCCK-AR and CCK-BR mRNA expression and cellular distribution in the rat lung were detected by highly sensitive method of in situ reverse transcription-polymerase chain reaction (RT-PCR) and conventional in situ hybridization.

resultsCCK-AR and CCK-BR gene positive signals were observed in bronchial epithelial cells, alveolar epithelial cells, pulmonary macrophages and vascular endothelial cells of the rats' lung by in situ RT-PCR. The hybridization signals of CCK-AR were relatively faint. By in situ hybridization, however, only the signals of CCK-BR but not CCK-AR were detected in the lung, and the positive staining was only found in vascular endothelial cells and macrophages.

conclusionCCK-AR and CCK-BR gene were present in pulmonary vascular endothelial cells, macrophages, bronchial epithelial cells and alveolar epithelial cells, which play an important role in mediating the regulatory actions of CCK-8 on these cells.

Indexed as

AnimalsIn Situ HybridizationLungRatsRats, Sprague-DawleyReceptor, Cholecystokinin AReceptor, Cholecystokinin BReceptors, CholecystokininReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTissue DistributionReceptor, Cholecystokinin AReceptor, Cholecystokinin BReceptors, CholecystokininRNA, Messenger

Identifiers

PMID12800239
PMCPMC4611799
OpenAlexW179291158

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.