ArticleWorld journal of gastroenterology2003
Antralization at the edge of proximal gastric ulcers: does Helicobacter pylori infection play a role?
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Remodeling of the gastric environment inmSystems · 2024Article
- Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression.Cancer cell · 2023Article
- Histological changes associated with pyloric and pseudopyloric metaplasia after Helicobacter pylori eradication.Virchows Archiv : an international journal of pathology · 2020Article
- Antralization of the gastric mucosa of the incisura angularis and its gastrin expression.International journal of clinical and experimental pathology · 2009Article
- Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation.Journal of clinical pathology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect of H. pylori eradication on the mucosal appearances.
methodsBiopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type. H. pylori positive patients received either triple therapy, or omeprazole.
resultsPatients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge in H. pylori-positive patients than H. pylori-negative patients (93 % vs 60 %, OR=8.95, 95 %CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61 %, P=0.004) at the ulcer edge in patients with H. pylori being eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.
conclusionH. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.
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