ArticleWorld journal of gastroenterology2003
Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium.
Article in World journal of gastroenterology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- HPV prevalence in esophageal cancer: an updated systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Mucosal alpha-papillomaviruses are not associated with esophageal squamous cell carcinomas: Lack of mechanistic evidence from South Africa, China and Iran and from a world-wide meta-analysis.International journal of cancer · 2016Pooled it
- Pooled it
- Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis.Epidemiology and infection · 2014Pooled it
- Establishment and characterization of a new human gallbladder cancer cell line, OCUG-2.World journal of experimental medicine · 2025Article
- Review
- Human Papillomavirus Infection and Oropharyngeal and Gastrointestinal Cancers: A Causal Relationship?Diseases (Basel, Switzerland) · 2022Review
- p16 in highly malignant esophageal carcinomas: the correlation with clinicopathological factors and human papillomavirus infection.Virchows Archiv : an international journal of pathology · 2021Article
- Detection of HPV16 in Esophageal Cancer in a High-Incidence Region of Malawi.International journal of molecular sciences · 2018Article
- Comparison Between Two Detection Methods for HPV16, HPV18 and P16Ink4a Biomarkers in Diagnosis of Abnormal Cervical CytologyAsian Pacific journal of cancer prevention : APJCP · 2016Article
- Human papillomavirus and the risk of Barrett's esophagus.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2013Article
- Squamous dysplasia--the precursor lesion for esophageal squamous cell carcinoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- Vaccination against human papilloma virus (HPV): epidemiological evidence of HPV in non-genital cancers.Pathology oncology research : POR · 2011Review
- Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers.World journal of gastroenterology · 2010Article
- Human papillomavirus in high- and low-risk areas of oesophageal squamous cell carcinoma in China.British journal of cancer · 2007Article
- Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile.World journal of gastroenterology · 2006Article
- Increased E2F-1 expression via tumour cell proliferation and decreased apoptosis are correlated with adverse prognosis in patients with squamous cell carcinoma of the oesophagus.Journal of clinical pathology · 2005Article
- Regulation of apoptosis by the papillomavirus E6 oncogene.World journal of gastroenterology · 2005Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the putative role of human papillomavirus (HPV) infection in the carcinogenesis of esophageal squamous cell carcinoma in China.
methodsTwenty-three esophageal squamous cell carcinoma samples and the distal normal epithelium from Shanxi Province, and 25 more esophageal squamous cell carcinoma samples from Anyang city, two areas with a high incidence of esophageal cancer in China, were detected for the existence of HPV-16 DNA by PCR, mRNA in situ hybridization (ISH) and immunohistochemistry (IHC) targeting HPV-16 E6 gene.
resultsThere were approximately 64 % (31/48) patients having HPV-16 DNA in tumor samples, among them nearly two-thirds (19/31) samples were detected with mRNA expression of HPV-16 E6. However, in the normal esophageal epithelium from cancer patients, the DNA and mRNA of HPV-16 were found with much less rate: 34.7 % (8/23) and 26.1 % (6/23) respectively. In addition, at protein level detected by IHC assay, 27.1 % (13/48) tumor samples had virus oncoprotein E6 expression, while only one case of normal epithelium was found positive.
conclusionHPV infection, especially type 16, should be considered as a risk factor for esophageal malignancies in China.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.