ArticleBritish journal of cancer2003
The combination of angiogenesis and blood vessel invasion as a prognostic indicator in primary breast cancer.
Article in British journal of cancer, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- High lymphatic vessel density and presence of lymphovascular invasion both predict poor prognosis in breast cancer.BMC cancer · 2017Pooled it
- The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Intratumoral and peritumoral lymphatic vessel density both correlate with lymph node metastasis in breast cancer.Scientific reports · 2017Pooled it
- Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: a systematic review and meta-analysis of the literature.Molecular biology reports · 2012Pooled it
- Pooled it
- Adverse prognostic value of peritumoral vascular invasion: is it abrogated by adequate endocrine adjuvant therapy? Results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy for early breast cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2010Trial
- Differences in tumor angiogenesis and related factors between lung adenocarcinomas manifesting as pure ground glass opacity and solid nodules.Discover oncology · 2025Article
- Tissue Microvessel Density as a Potential Predictive Marker for Vascular Invasion in Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Prognostic value of tumor necrosis based on the evaluation of frequency in invasive breast cancer.BMC cancer · 2023Article
- Characterization of the Tumor Microenvironment and the Biological Processes with a Role in Prostatic Tumorigenesis.Biomedicines · 2022Article
- TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.Molecular oncology · 2022Article
- Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer.PloS one · 2021Article
- Pre-treatment systemic immune-inflammation index is a useful prognostic indicator in patients with breast cancer undergoing neoadjuvant chemotherapy.Journal of cellular and molecular medicine · 2020Article
- Prognostic impact of lymphatic invasion for pathological stage I squamous cell carcinoma of the lung.General thoracic and cardiovascular surgery · 2015Article
- Different types of tumor vessels in breast cancer: morphology and clinical value.SpringerPlus · 2015Article
- Immunohistochemical detection improves the prognostic value of lymphatic and blood vessel invasion in primary ductal breast cancer.BMC cancer · 2014Article
- Amplification of Genomic DNA for Decoy Receptor 3 Predicts Post-Resection Disease Recurrence in Breast Cancer Patients.World journal of oncology · 2014Article
- Blood vessel invasion and other variables as predictors of long-term survival in Japanese and British patients with primary invasive breast cancer.International journal of clinical and experimental pathology · 2014Article
- The relationship between lymphovascular invasion and angiogenesis, hormone receptors, cell proliferation and survival in patients with primary operable invasive ductal breast cancer.BMC clinical pathology · 2013Article
- Interdisciplinary GoR level III Guidelines for the Diagnosis, Therapy and Follow-up Care of Breast Cancer: Short version - AWMF Registry No.: 032-045OL AWMF-Register-Nummer: 032-045OL - Kurzversion 3.0, Juli 2012.Geburtshilfe und Frauenheilkunde · 2013Article
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5 authors.
Funding
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Abstract
This study was undertaken to examine the interaction between the combination of angiogenesis and blood vessel invasion (BVI) and haematogenous metastasis, and to determine the prognostic significance of that combination in predicting 20-year relapse-free survival (RFS) and overall survival (OS) rates in primary breast cancer. Five hundred and nine patients were studied. We investigated 11 factors, including average microvessel count (AMC)/BVI, lymph-node status (n), clinical tumour size (T), histological grade (HG), lymphatic vessel invasion (LVI), p53, proliferating cell nuclear antigen (PCNA), c-erbB-2, mitotic index (MI), apoptotic index, and tumour necrosis (TN). Blood vessel invasion was detected by both factor VIII-related antigen and elastica van Gieson staining. To evaluate the best objective method to quantify microvessel density in angiogenesis, AMC was employed. The rate of AMC-high and BVI-positive tumours was 32.6 and 29.3%, respectively. That of both AMC-high and BVI-positive tumours was 10.1%. Univariate analysis showed that AMC/BVI, n, T, HG, LVI, p53, PCNA, MI, and TN were significantly predictive of RFS and OS. By multivariate analysis, AMC/BVI was the strongest independent prognostic factor for 20-year RFS (relative risk (RR)=5.5; P<0.0001) and for 20-year OS (RR=4.3; P<0.0001). Lymph-node status was still considered a powerful prognostic indicator; however, the combination of AMC and BVI provided more reliable prognostic information than lymph-node status for haematogenous dissemination.
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