ArticleNucleic acids research2003
The SV40 T antigen modulates CBP histone acetyltransferase activity.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
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- Adenovirus-Mediated Gene Delivery: Potential Applications for Gene and Cell-Based Therapies in the New Era of Personalized Medicine.Genes & diseases · 2017Article
- KATs in cancer: functions and therapies.Oncogene · 2015Review
- PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocarcinoma progression.Nucleic acids research · 2015Article
- Life cycle and pathogenesis of hepatitis D virus: A review.World journal of hepatology · 2013Review
- Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.Journal of virology · 2013Article
- hTERT extends the life of human fibroblasts without compromising type I interferon signaling.PloS one · 2013Article
- Epigenetic modulation of host: new insights into immune evasion by viruses.Journal of biosciences · 2010Review
- Genotyping schemes for polyomavirus BK, using gene-specific phylogenetic trees and single nucleotide polymorphism analysis.Journal of virology · 2009Article
- Biologic diversity of polyomavirus BK genomic sequences: Implications for molecular diagnostic laboratories.Journal of medical virology · 2008Article
- Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation.Nucleic acids research · 2007Article
- Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.Journal of virology · 2006Article
- Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA.Molecular and cellular biology · 2006Article
- SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Oncogene · 2005Review
- Epigenetic mechanisms affect mutant p53 transgene expression in WAP-mutp53 transgenic mice.Oncogene · 2005Article
- Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy.Journal of virology · 2005Article
- p53 targets simian virus 40 large T antigen for acetylation by CBP.Journal of virology · 2004Article
- The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.Nucleic acids research · 2004Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone acetyltransferases (HATs) play a key role in transcription control, cell proliferation and differentiation by modulating chromatin structure; however, little is known about their own regulation. Here we show that expression of the viral oncoprotein SV40 T antigen increases histone acetylation and global cellular HAT activities. In addition, it enhances CREB-binding protein HAT activity and modulates its transcriptional activity. Finally, we show that inhibition of cellular histone deacetylases by trichostatin A increases the SV40 infectivity rate. These findings highlight the importance of histone acetylation in the regulation of the cell cycle by oncoviral proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.