ArticleEukaryotic cell2003
Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 22 citations in OpenAlex.
- Mitochondrial function regulates cell growth kinetics to maintain mitochondrial homeostasis.Current biology : CB · 2025Article
- R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.PLoS genetics · 2021Article
- Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.PLoS genetics · 2014Article
- Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.Molecular biology of the cell · 2013Article
- Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.Current biology : CB · 2013Article
- Polar opposites: Fine-tuning cytokinesis through SIN asymmetry.Cytoskeleton (Hoboken, N.J.) · 2012Review
- Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2011Review
- Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast.Genetics · 2010Article
- Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum.The Journal of biological chemistry · 2008Article
- Article
- A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.Genetics · 2006Article
- Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.Eukaryotic cell · 2005Article
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2 authors at 1 institution in 1 country.
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Abstract
Cytokinesis in the fission yeast Schizosaccharomyces pombe is regulated by a signaling pathway termed the septation initiation network (SIN). The SIN is essential for initiation of actomyosin ring constriction and septum formation. In a screen to search for mutations that can rescue the sid2-250 SIN mutant, we obtained scw1-18. Both the scw1-18 mutant and the scw1 deletion mutant (scw1Delta mutant), have defects in cell separation. Both the scw1-18 and scw1Delta mutations rescue the growth defects of not just the sid2-250 mutant but also the other temperature-sensitive SIN mutants. Other cytokinesis mutants, such as those defective for actomyosin ring formation, are not rescued by scw1Delta. scw1Delta does not seem to rescue the SIN by restoring SIN signaling defects. However, scw1Delta may function downstream of the SIN to promote septum formation, since scw1Delta can rescue the septum formation defects of the cps1-191beta-1,3-glucan synthase mutant, which is required for synthesis of the primary septum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.