ArticleEukaryotic cell2003
Candida albicans VPS11 is required for vacuole biogenesis and germ tube formation.
Article in Eukaryotic cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 61 citations in OpenAlex.
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Article
- The Importance of Vacuolar Ion Homeostasis and Trafficking in Hyphal Development and Virulence inFrontiers in microbiology · 2021Review
- Changes in the Ultrastructure ofMicroorganisms · 2020Article
- Inhibition of Vesicular Transport Influences Fungal Susceptibility to Fluconazole.Antimicrobial agents and chemotherapy · 2019Article
- Overexpression of the CORVET complex alleviates the fungicidal effects of fludioxonil on the yeastThe Journal of biological chemistry · 2019Article
- HOPS-dependent endosomal fusion required for efficient cytosolic delivery of therapeutic peptides and small proteins.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- TOR-autophagy branch signaling via Imp1 dictates plant-microbe biotrophic interface longevity.PLoS genetics · 2018Article
- A coupled process of same- and opposite-sex mating generates polyploidy and genetic diversity in Candida tropicalis.PLoS genetics · 2018Article
- Identification of small molecules that disrupt vacuolar function in the pathogen Candida albicans.PloS one · 2017Article
- Article
- Discovery of the gray phenotype and white-gray-opaque tristable phenotypic transitions in Candida dubliniensis.Virulence · 2016Article
- Article
- ERG2 and ERG24 Are Required for Normal Vacuolar Physiology as Well as Candida albicans Pathogenicity in a Murine Model of Disseminated but Not Vaginal Candidiasis.Eukaryotic cell · 2015Article
- Trafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals.Antimicrobial agents and chemotherapy · 2015Article
- Intracellular aspartic proteinase Apr1p of Candida albicans is required for morphological transition under nitrogen-limited conditions but not for macrophage killing.Folia microbiologica · 2014Article
- Discovery of a "white-gray-opaque" tristable phenotypic switching system in candida albicans: roles of non-genetic diversity in host adaptation.PLoS biology · 2014Article
- Three prevacuolar compartment Rab GTPases impact Candida albicans hyphal growth.Eukaryotic cell · 2013Article
- PsVPS1, a dynamin-related protein, is involved in cyst germination and soybean infection of Phytophthora sojae.PloS one · 2013Article
- Candida albicans interactions with epithelial cells and mucosal immunity.Microbes and infection · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The Candida albicans vacuole has previously been observed to undergo rapid expansion during the emergence of a germ tube from a yeast cell, to occupy the majority of the parent yeast cell. Furthermore, the yeast-to-hypha switch has been implicated in the virulence of this organism. The class C vps (vacuolar protein sorting) mutants of Saccharomyces cerevisiae are defective in multiple protein delivery pathways to the vacuole and prevacuole compartment. In this study C. albicans homologues of the S. cerevisiae class C VPS genes have been identified. Deletion of a C. albicans VPS11 homologue resulted in a number of phenotypes that closely resemble those of the class C vps mutants of S. cerevisiae, including the absence of a vacuolar compartment. The C. albicans vps11Delta mutant also had much-reduced secreted lipase and aspartyl protease activities. Furthermore, vps11Delta strains were defective in yeast-hypha morphogenesis. Upon serum induction of filamentous growth, mutants showed delayed emergence of germ tubes, had a reduced apical extension rate compared to those of control strains, and were unable to form mature hyphae. These results suggest that Vps11p-mediated trafficking steps are necessary to support the rapid emergence and extension of the germ tube from the parent yeast cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.