Trial reportThe Journal of physiology2003
IL-6 gene expression in human adipose tissue in response to exercise--effect of carbohydrate ingestion.
Trial report in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 128 citations in OpenAlex.
- Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men.Cell reports. Medicine · 2021Trial
- Exercise training alters the genomic response to acute exercise in human adipose tissue.Epigenomics · 2018Trial
- Interferon-β induction heterogeneity during KSHV infection is correlated to levels and activation of the transcription factors ATF2 and RelA, and not IRF3.PLoS pathogens · 2026Article
- Molecular responses in abdominal subcutaneous adipose tissue after a session of endurance exercise: effects of exercise intensity.The Journal of physiology · 2025Article
- Acute session of three endurance exercise intensities alters subcutaneous adipose tissue transcriptome in regular exercisers.bioRxiv : the preprint server for biology · 2025Article
- The Influence of Diet and Physical Activity on Periodontal Health: A Narrative Review.Dentistry journal · 2025Review
- Liraglutide attenuates obese-associated breast cancer cell proliferation via inhibiting PI3K/Akt/mTOR signaling pathway.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Platelet lysate can support the development of a 3D-engineered skin for clinical application.Cell and tissue research · 2023Article
- Human adipose and skeletal muscle tissue DNA, RNA, and protein content.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Diabetes induced renal complications by leukocyte activation of nuclear factor κ-B and its regulated genes expression.Saudi journal of biological sciences · 2021Article
- Review
- Characterization and Modulation of Systemic Inflammatory Response to Exhaustive Exercise in Relation to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2020Review
- Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle.Nutrients · 2019Article
- The compelling link between physical activity and the body's defense system.Journal of sport and health science · 2019Review
- Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver.Biochemical and biophysical research communications · 2019Article
- Muscle Glycogen Depletion Following 75-km of Cycling Is Not Linked to Increased Muscle IL-6, IL-8, and MCP-1 mRNA Expression and Protein Content.Frontiers in physiology · 2016Article
- Effect of Nigella sativa on immune response in treadmill exercised rat.BMC complementary and alternative medicine · 2014Article
- A complex signaling network involving protein kinase CK2 is required for hepatitis C virus core protein-mediated modulation of the iron-regulatory hepcidin gene expression.Cellular and molecular life sciences : CMLS · 2014Article
- Evaluation of immune response after moderate and overtraining exercise in wistar rat.Iranian journal of basic medical sciences · 2014Article
- Effects of exercise training on chronic inflammation in obesity : current evidence and potential mechanisms.Sports medicine (Auckland, N.Z.) · 2013 · on this mapReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-6 (IL-6) is a cytokine involved in a number of immunological processes, but it is also linked to exercise and possibly energy status. During exercise, muscle IL-6 mRNA levels and plasma IL-6 levels are increased and further augmented when intramuscular glycogen levels are low. In contrast, the increase in plasma IL-6 is blunted if carbohydrate is administered, indicating a substrate-regulated induction of IL-6 in human skeletal muscle. Recent studies have demonstrated that IL-6 is also released from adipose tissue in response to an exercise bout. Furthermore, IL-6 has been demonstrated to have a lipolytic effect, thus possibly playing a role in mobilisation of energy as free fatty acids (FFA) in response to exercise. The purpose of the present study was to investigate the gene expression pattern of IL-6 in adipose tissue in response to exercise, and to determine whether gene expression was affected by the ingestion of carbohydrate. Eight male subjects performed 3 h of bicycling with ingestion of a carbohydrate drink or placebo. Fat biopsy samples and blood samples were obtained before, during and in the recovery phase of exercise. Both plasma IL-6 and adipose IL-6 mRNA levels increased in response to exercise. IL-6 gene expression was lower (P<0.05) in the CHO trial (1.98-fold increase, confidence interval (CI) 1.16-3.83) compared with the control (6.49-fold increase, CI 3.57-13.91) at end of exercise. Furthermore, CHO ingestion blunted the increase in plasma IL-6 levels (P<0.05) at end of exercise (26.0+/-3.7 pg ml(-1) in the control vs. 15.6+/-2.4 pg ml(-1) in the CHO trial). In conclusion, exercise results in an increase in IL-6 gene expression in adipose tissue in response to exercise, an effect that is significantly blunted by ingestion of carbohydrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.