ArticleJournal of virology1992
The receptor for mouse hepatitis virus in the resistant mouse strain SJL is functional: implications for the requirement of a second factor for viral infection.
Article in Journal of virology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 67 citations in OpenAlex.
- Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection.Frontiers in microbiology · 2012Article
- Cytopathy of an infiltrating monocyte lineage during the early phase of infection with murinecoronavirus in the brain.Neuropathology : official journal of the Japanese Society of Neuropathology · 2010Article
- Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b.Journal of virology · 2010Article
- The spike glycoprotein of murine coronavirus MHV-JHM mediates receptor-independent infection and spread in the central nervous systems of Ceacam1a-/- Mice.Journal of virology · 2008Article
- Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice.Virology · 2006Article
- Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release.Journal of virology · 2005Article
- Receptor-independent spread of a highly neurotropic murine coronavirus JHMV strain from initially infected microglial cells in mixed neural cultures.Journal of virology · 2005Article
- Expression of the mouse hepatitis virus receptor by central nervous system microglia.Journal of virology · 2004Article
- Receptor-dependent coronavirus infection of dendritic cells.Journal of virology · 2004Article
- N-terminal domain of the murine coronavirus receptor CEACAM1 is responsible for fusogenic activation and conformational changes of the spike protein.Journal of virology · 2004Article
- The N-terminal domain of the murine coronavirus spike glycoprotein determines the CEACAM1 receptor specificity of the virus strain.Journal of virology · 2003Article
- Receptor-induced conformational changes of murine coronavirus spike protein.Journal of virology · 2002Article
- Article
- Soluble receptor potentiates receptor-independent infection by murine coronavirus.Journal of virology · 2002Article
- Targeted disruption of the Ceacam1 (MHVR) gene leads to reduced susceptibility of mice to mouse hepatitis virus infection.Journal of virology · 2001Article
- B-cell-mediated lysis of cells infected with the neurotropic JHM strain of mouse hepatitis virus.Virology · 2001Article
- Purified, soluble recombinant mouse hepatitis virus receptor, Bgp1(b), and Bgp2 murine coronavirus receptors differ in mouse hepatitis virus binding and neutralizing activities.Journal of virology · 1998Article
- Mutational analysis of the virus and monoclonal antibody binding sites in MHVR, the cellular receptor of the murine coronavirus mouse hepatitis virus strain A59.Journal of virology · 1998Article
- Mouse hepatitis virus infection induces an early, transient calcium influx in mouse astrocytoma cells.Experimental cell research · 1997Article
- Mouse susceptibility to mouse hepatitis virus infection is linked to viral receptor genotype.Journal of virology · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The SJL mouse strain is resistant to infection by some strains of the murine coronavirus mouse hepatitis virus (MHV), such as JHM and A59. The block to virus infection has been variously attributed to defects in virus receptors or virus spread. Since the cellular receptors for MHV, mmCGM1 and mmCGM2, have recently been identified as members of the carcinoembryonic antigen family, we reexamined the possible defectiveness of the MHV receptors in SJL mouse strain. Cloning and sequencing of the cDNAs of both mmCGMs RNAs from SJL mice revealed that they were identical in size to those of the susceptible C57BL/6 (B6) mouse. There was some sequence divergence in the N terminus of the mmCGM molecules between the two mouse strains, resulting in a different number of potential glycosylation sites. This was confirmed by in vitro translation of the mmCGM RNAs, which showed that the glycosylated mmCGM2 of SJL was smaller than that of B6 mice. However, transfection of either mmCGM1 or mmCGM2 from SJL mice into MHV-resistant Cos 7 cells rendered the cells susceptible to MHV infection. The ability of the SJL mmCGM molecules to serve as MHV receptors was comparable to that of those from B6. These molecules are expressed in SJL mouse brain and liver in a similar ratio and in amounts equivalent to those in the B6 mouse. Furthermore, we demonstrated that an SJL-derived cell line was susceptible to A59 but resistant to JHM infection. We concluded that the MHV receptor molecules in the SJL mouse are functional and that the resistance of SJL mice to infection by some MHV strains most likely results from some other factor(s) required for virus entry or some other step(s) in virus replication.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.