ArticleJournal of clinical microbiology2003
Characterization of the 8-kilodalton antigens of Taenia solium metacestodes and evaluation of their use in an enzyme-linked immunosorbent assay for serodiagnosis.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 97 citations in OpenAlex.
- From laboratory to clinical practice: an update of the immunological and molecular tools for neurocysticercosis diagnosis.Frontiers in parasitology · 2024Review
- Antibody Banding Patterns on the Enzyme-Linked Immunoelectrotransfer Blot (EITB) Assay Clearly Discriminate Viable Cysticercosis in Naturally Infected Pigs.Pathogens (Basel, Switzerland) · 2023Article
- Multiantigen print immunoassay (MAPIA) for the diagnosis of neurocysticercosis: a single-center diagnostic optimization and accuracy study in Lima, Peru.Journal of clinical microbiology · 2023Article
- Triplex ELISA for Assessing Durability of Taenia solium Seropositivity after Neurocysticercosis Cure.Emerging infectious diseases · 2023Article
- Improved Diagnosis of Viable Parenchymal Neurocysticercosis by Combining Antibody Banding Patterns on Enzyme-Linked Immunoelectrotransfer Blot (EITB) with Antigen Enzyme-Linked Immunosorbent Assay (ELISA).Journal of clinical microbiology · 2022Article
- Comparative Transcriptome Analyses of the Developmental Stages ofFrontiers in veterinary science · 2021Article
- Advances in Serological Diagnosis of Taenia solium Neurocysticercosis in Korea.Genomics & informatics · 2019Article
- Evaluation of cross-reactivity to Taenia hydatigena and Echinococcus granulosus in the enzyme-linked immunoelectrotransfer blot assay for the diagnosis of porcine cysticercosis.Parasites & vectors · 2019Article
- Laboratory Diagnosis of Neurocysticercosis (Taenia solium).Journal of clinical microbiology · 2018Review
- Antibody Banding Patterns of the Enzyme-Linked Immunoelectrotransfer Blot and Brain Imaging Findings in Patients With Neurocysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Taenia solium metacestode preparation in rural areas of sub-Saharan Africa: a source for diagnosis and research on cysticercosis.African health sciences · 2015Article
- Feasibility of a lateral flow test for neurocysticercosis using novel up-converting nanomaterials and a lightweight strip analyzer.PLoS neglected tropical diseases · 2014Article
- Recombinant protein- and synthetic peptide-based immunoblot test for diagnosis of neurocysticercosis.Journal of clinical microbiology · 2014Article
- Neurocysticercosis: A disease of neglect.Tropical parasitology · 2013Review
- Use of expressed sequence tags as an alternative approach for the identification of Taenia solium metacestode excretion/secretion proteins.BMC research notes · 2013Article
- Immunological and molecular diagnosis of cysticercosis.Pathogens and global health · 2012Review
- Serologic diagnosis of human Taenia solium cysticercosis by using recombinant and synthetic antigens in QuickELISA™.The American journal of tropical medicine and hygiene · 2011Article
- Immunoinformatics prediction of linear epitopes from Taenia solium TSOL18.Bioinformation · 2011Article
- Immunodiagnosis of neurocysticercosis: ways to focus on the challenge.Journal of biomedicine & biotechnology · 2011Review
- Protein and antigen diversity in the vesicular fluid of Taenia solium cysticerci dissected from naturally infected pigs.International journal of biological sciences · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The Western blot for cysticercosis, which uses lentil lectin purified glycoprotein (LLGP) antigens extracted from the metacestode of Taenia solium, has been the "gold standard" serodiagnostic assay since it was first described in 1989. We report that the diagnostic antigens at 14, 18, and 21 kDa, as well as some larger disulfide-bonded antigens, are actually all members of a very closely related family of proteins, the 8-kDa antigens. The genes for 18 unique, mature proteins have been identified. Nine of these were chemically synthesized and tested in an enzyme-linked immunosorbent assay with a battery of defined serum samples, including 32 cysticercosis-positive serum samples reactive with the 8-kDa antigens of LLGP on Western blotting, 34 serum samples from patients with other parasitic infections, and 15 normal human serum samples. One of the 8-kDa antigens, TsRS1, is 100% sensitive and 100% specific. TsRS1 will be one component of a cocktail of three to four synthetic or recombinant antigens, based on the diagnostic bands of the Western blot, which will be used for the serodiagnosis of cysticercosis.
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