ArticleJournal of clinical microbiology2003
Genetic biodiversity of Mycobacterium tuberculosis complex strains from patients with pulmonary tuberculosis in Cameroon.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Beijing/W genotype Mycobacterium tuberculosis and drug resistance.Emerging infectious diseases · 2006Pooled it
- Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana.PloS one · 2014Trial
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- Epidemiological surveillance of tuberculosis-HIV co-infection and genotypic strains of theThe Pan African medical journal · 2025Article
- Mycobacterium tuberculosis complex drug-resistance, phylogenetics, and evolution in Nigeria: Comparison with Ghana and Cameroon.PLoS neglected tropical diseases · 2023Review
- Non-Mycobacteria Tuberculosis in Africa: A Literature Review.Ethiopian journal of health sciences · 2023Review
- Prevalence and molecular characterization of Mycobacterium tuberculosis complex in cattle and humans, Maiduguri, Borno state, Nigeria: a cross-sectional study.BMC microbiology · 2023Article
- Biodiversity ofMicroorganisms · 2022Article
- Molecular snapshot of drug-resistant Mycobacterium tuberculosis strains from the Plateau State, Nigeria.PloS one · 2022Article
- Molecular epidemiology and multidrug resistance ofHeliyon · 2021Article
- Genetic variability in multidrug-resistant Mycobacterium tuberculosis isolates from patients with pulmonary tuberculosis in North India.BMC microbiology · 2021Article
- The Relevance of Genomic Epidemiology for Control of Tuberculosis in West Africa.Frontiers in public health · 2021Review
- Diversity ofTuberculosis research and treatment · 2021Article
- A pilot study on the genetic diversity ofJournal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region.Nature communications · 2020Article
- Evolution of Mycobacterium tuberculosis complex lineages and their role in an emerging threat of multidrug resistant tuberculosis in Bamako, Mali.Scientific reports · 2020Article
- Comparative genomics shows differences in the electron transport and carbon metabolic pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension.Tuberculosis (Edinburgh, Scotland) · 2020Article
- Molecular Analysis ofJournal of epidemiology and global health · 2019Article
- Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria.PloS one · 2019Article
18 more citing papers are in PubMed but not listed here.
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed DNA polymorphisms in 455 Mycobacterium tuberculosis complex isolates from 455 patients to evaluate the biodiversity of tubercle bacilli in Ouest province, Cameroon. The phenotypic and genotypic identification methods gave concordant results for 99.5% of M. tuberculosis isolates (413 strains) and for 90% of Mycobacterium africanum isolates (41 strains). Mycobacterium bovis was isolated from only one patient. Analysis of regions of difference (RD4, RD9, and RD10) proved to be an accurate and rapid method of distinguishing between unusual members of the M. tuberculosis complex. Whereas M. africanum strains were the etiologic agent of tuberculosis in 56% of cases 3 decades ago, our results showed that these strains now account for just 9% of cases of tuberculosis. We identified a group of closely genetically related M. tuberculosis strains that are currently responsible for >40% of smear-positive pulmonary tuberculosis cases in this region of Cameroon. These strains shared a spoligotype lacking spacers 23, 24, and 25 and had highly related IS6110 ligation-mediated (LM) PCR patterns. They were designated the "Cameroon family." We did not find any significant association between tuberculosis-causing species or strain families and patient characteristics (sex, age, and human immunodeficiency virus status). A comparison of the spoligotypes of the Cameroon strains with an international spoligotype database (SpolDB3) containing 11,708 patterns from >90 countries, showed that the predominant spoligotype in Cameroon was limited to West African countries (Benin, Senegal, and Ivory Coast) and to the Caribbean area.
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