ArticleCell motility and the cytoskeleton2003
Requirement for the betaI and betaIV tubulin isotypes in mammalian cilia.
Article in Cell motility and the cytoskeleton, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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31 citing papers in PubMed, 49 citations in OpenAlex.
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- Tubulin E-hook Hexamers Reveal Charge Dependent Compaction and Transient Secondary Structure Signatures.bioRxiv : the preprint server for biology · 2026Article
- Screening the composition of tubulin isotypes reveals the most abundant TUBB4B for ciliary polarity in ependymal cells.Journal of molecular cell biology · 2026Article
- Computational perspectives on tubulin E-hook structure and mechanisms.Biophysical reports · 2026Review
- IL-13 May Could Enhance the Proliferation and Affect the Differentiation of Nasal Epithelium Basal Cells Through the mTOR/p70S6K1 Pathway in Chronic Rhinosinusitis With Nasal Polyps.Mediators of inflammation · 2025Article
- Characterization of a primary cellular airway model for inhalative drug delivery in comparison with the established permanent cell lines CaLu3 and RPMI 2650.In vitro models · 2024Article
- TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development.Communications biology · 2024Article
- Article
- The Influenza B Virus Victoria and Yamagata Lineages Display Distinct Cell Tropism and Infection Induced Host Gene Expression in Human Nasal Epithelial Cell Cultures.bioRxiv : the preprint server for biology · 2023Article
- Regulation of Tubulin Gene Expression: From Isotype Identity to Functional Specialization.Frontiers in cell and developmental biology · 2022Review
- MRI Features in a Rat Model of H-ABC Tubulinopathy.Frontiers in neuroscience · 2020Article
- The dynamic and structural properties of axonemal tubulins support the high length stability of cilia.Nature communications · 2019Article
- Review
- How cells exploit tubulin diversity to build functional cellular microtubule mosaics.Current opinion in cell biology · 2019Review
- An essential role for α4A-tubulin in platelet biogenesis.Life science alliance · 2019Article
- Crystal structure of tubulin tyrosine ligase-like 3 reveals essential architectural elements unique to tubulin monoglycylases.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Quantitative Proteomic Analysis of Human Airway Cilia Identifies Previously Uncharacterized Proteins of High Abundance.Journal of proteome research · 2017Article
- Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.Molecular biology of the cell · 2015Article
- CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells.The Journal of general virology · 2015Article
- A simple method to obtain pure cultures of multiciliated ependymal cells from adult rodents.Histochemistry and cell biology · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Nielsen et al., [2001: Curr Biol 11:529-533], based on studies in Drosophila, have proposed that beta tubulin in axonemal microtubules must contain a specific acidic seven amino acid sequence in its carboxyl terminus. In mammals, the two betaIV isotypes (betaIVa and betaIVb) contain that sequence. In order to test the application of this hypothesis to mammals, we have examined the expression of beta tubulin isotypes in four different ciliated tissues (trachea, ependyma, uterine tube, and testis) using isotype-specific antibodies and indirect immunofluorescence. We find that betaIV tubulin is present in all ciliated cell types examined, but so is betaI tubulin. Taken together with recent studies that show that betaI and betaIV tubulin are both present in the cilia of vestibular hair cells, olfactory neurons, and nasal respiratory epithelial cells, we propose that both betaI tubulin and betaIV tubulin may be required for axonemal structures in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.