ArticleInternational journal of impotence research2003
Histological and functional aspects of different regions of the rabbit vagina.
Article in International journal of impotence research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Reducing Hormonal Inputs in Rabbit Reproduction: Physical Ovulation Induction with a 3D-Printed Cannula.Animals : an open access journal from MDPI · 2025Article
- Advances in vaginal bioengineering: Applications, techniques, and needs.Current research in physiology · 2023Review
- Establishment of Rat Model of Female Genital Sexual Arousal Disorder.Sexual medicine · 2022Article
- Smooth Muscle Organization and Nerves in the Rat Vagina: A First Look Using Tissue Clearing and Immunolabeling.Annals of biomedical engineering · 2022Article
- Animal Models and Alternatives in Vaginal Research: a Comparative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
- Nerve-induced responses of mouse vaginal smooth muscle.Pflugers Archiv : European journal of physiology · 2017Article
- Expression and significance of TIMP-3, PACAP and VIP in vaginal wall tissues of patients with stress urinary incontinence.Experimental and therapeutic medicine · 2017Article
- Phasic contractions of the mouse vagina and cervix at different phases of the estrus cycle and during late pregnancy.PloS one · 2014Article
- Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis.The journal of sexual medicine · 2013Article
- Regional differences in rat vaginal smooth muscle contractility and morphology.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Adaptive plasticity of vaginal innervation in term pregnant rats.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Functional significance of muscarinic receptor expression within the proximal and distal rat vagina.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Endothelial nitric oxide synthase regulation in female genital tract structures.The journal of sexual medicine · 2009Review
- General tissue characteristics of the lower urethral and vaginal walls in the domestic rabbit.International urogynecology journal and pelvic floor dysfunction · 2009Article
- Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse.International urogynecology journal and pelvic floor dysfunction · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relatively little data is available on regional differences in both morphological and functional studies of vaginal smooth muscle in the rabbit. Histological and in vitro strip studies were performed upon the vaginal walls of 10-week-old New Zealand White rabbits discriminately according to location (upper, middle or lower) and the type of muscle arrangement (longitudinal or circular). The contraction and relaxation responses of the vaginal smooth muscle were assessed. The upper and middle third of the vagina were histologically characterized by an abundance of smooth muscle, while the lower third was composed of numerous sinusoids scattered among smooth muscle bundles. The peak amplitudes of 60 mM KCl-induced contraction per tissue strip weight were regionally different (upper>middle>lower). Contractile responses induced by adrenergic agonists (epinephrine, norepinephrine, phenylephrine and isopreterenol) showed regional differences, and were mainly of a tonic nature in lower part and strong phasic in middle and upper vagina. Electrical field stimulation induced a prominent relaxation response in the lower third of the vagina precontracted with phenylephrine (5 microM). This relaxation response was partially inhibited by N-omega-nitro-L-arginine methyl ester (NAME, 43.3+/-6.9%, s.e.), a nitric oxide synthase inhibitor, and D-vasoactive intestinal peptide (VIP) (11.3+/-4.4%), a VIP receptor antagonist. The type of muscle arrangement did not affect the results. Our results demonstrated that rabbit vagina has regional difference, not only histologically but also functionally. The contractile response was induced in all regions of the rabbit vagina by sympathetic agonists, while the prominent nerve-mediated relaxation was identified in the lower third portion of the rabbit vagina. The nature of relaxation and contractile function of vagina awaits future investigation.
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