ArticleOncogene2003
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- miR-663b promotes colorectal cancer progression by activating Ras/Raf signaling through downregulation of TNK1.Human cell · 2020Article
- Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.The Journal of clinical investigation · 2018Article
- Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway inOncotarget · 2018Article
- Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.Molecular cancer · 2018Review
- Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Drosophila activated Cdc42 kinase has an anti-apoptotic function.PLoS genetics · 2012Article
- High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.Molecular cancer research : MCR · 2011Article
- Regulation of ack-family nonreceptor tyrosine kinases.Journal of signal transduction · 2011Article
- Regulation of Ack1 localization and activity by the amino-terminal SAM domain.BMC biochemistry · 2010Article
- Tnk1/Kos1: a novel tumor suppressor.Transactions of the American Clinical and Climatological Association · 2010Review
- Identification of protein tyrosine kinases with oncogenic potential using a retroviral insertion mutagenesis screen.Haematologica · 2009Article
- Article
- Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.Molecular biology of the cell · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Kinase of embryonic stem cells (Kos1), a nonreceptor protein tyrosine kinase (NRPTK), was identified and cloned from differentiating murine embryonic stem cells. Kos1 is localized on mouse chromosome 11 that corresponds to human chromosome 17p13.1 and is homologous to Tnk1, Ack1 and Ack2, making it a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Stable overexpression of Kos1 inhibits growth of NIH 3T3 cells, while the kinase-dead Kos1(CN) promotes cell growth in both liquid culture and soft agar. In addition, forced expression of Kos1 inhibits Ras activity in an indirect mechanism that results in the downregulation of the Ras-Raf1-MAPK growth pathway. Furthermore, overexpression of Kos1 in NCI-H82 lung cancer cells that express oncogenic Ha-Ras(G12V) inhibits cell growth under reduced serum (0.5%) conditions in close association with the upregulation of the Ras inhibitor, Rap1A. Collectively, these data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.