Evidence map›Paper›PMID 12788993›Full record

Trial reportThe New England journal of medicine2003

Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus.

David M Nathan, John Lachin, Patricia Cleary, Trevor Orchard, David J Brillon, Jye-Yu Backlund, Daniel H O'Leary, Saul Genuth, Diabetes Control and Complications Trial, Epidemiology of Diabetes Interventions and Complications Research Group

Registry-linked trialAbstract readClinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The New England journal of medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00360893 (Epidemiology of Diabetes Interventions and Complications), which is not on this map. Cited by 261 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
261citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00360893 active not recruitingnot on this map

Epidemiology of Diabetes Interventions and Complications (EDIC)

TypeobservationalSponsorGeorge Washington UniversityRan1994 to 2027Enrolled1,441ConditionsType 1 Diabetes Mellitus
3 · Its place in the literature

Who cites it

261 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Impact of Islet Transplantation on Type 1 Diabetes-Related Complication: A Systematic Review.Transplant international : official journal of the European Society for Organ Transplantation · 2025
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201 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

David M NathanDCCT/EDIC Research Group at Box NDIC/DCCT, Bethesda, MD 20892, USA. dnathan@partners.org
John Lachin
Patricia Cleary
Trevor Orchard
David J Brillon
Jye-Yu Backlund
Daniel H O'Leary
Saul Genuth
Diabetes Control and Complications Trial
Epidemiology of Diabetes Interventions and Complications Research Group

Funding

EPIDEMIOLOGY OF DIABETES INTERVENTIONS &COMPLICATIONSN01DK062204 · NIDDK · GEORGE WASHINGTON UNIVERSITY · 1996 to 2004
$2.1M
NIDDK NIH HHS N01 DK062204
6 · The paper itself

Abstract

backgroundCardiovascular disease causes severe morbidity and mortality in type 1 diabetes, although the specific risk factors and whether chronic hyperglycemia has a role are unknown. We examined the progression of carotid intima-media thickness, a measure of atherosclerosis, in a population with type 1 diabetes.

methodsAs part of the Epidemiology of Diabetes Interventions and Complications (EDIC) study, the long-term follow-up of the Diabetes Control and Complications Trial (DCCT), 1229 patients with type 1 diabetes underwent B-mode ultrasonography of the internal and common carotid arteries in 1994-1996 and again in 1998-2000. We assessed the intima-media thickness in 611 subjects who had been randomly assigned to receive conventional diabetes treatment during the DCCT and in 618 who had been assigned to receive intensive diabetes treatment.

resultsAt year 1 of the EDIC study, the carotid intima-media thickness was similar to that in an age- and sex-matched nondiabetic population. After six years, the intima-media thickness was significantly greater in the diabetic patients than in the controls. The mean progression of the intima-media thickness was significantly less in the group that had received intensive therapy during the DCCT than in the group that had received conventional therapy (progression of the intima-media thickness of the common carotid artery, 0.032 vs. 0.046 mm; P=0.01; and progression of the combined intima-media thickness of the common and internal carotid arteries, -0.155 vs. 0.007; P=0.02) after adjustment for other risk factors. Progression of carotid intima-media thickness was associated with age, and the EDIC base-line systolic blood pressure, smoking, the ratio of low-density lipoprotein to high-density lipoprotein cholesterol, and urinary albumin excretion rate and with the mean glycosylated hemoglobin value during the mean duration (6.5 years) of the DCCT.

conclusionsIntensive therapy during the DCCT resulted in decreased progression of intima-media thickness six years after the end of the trial.

Indexed as

AdolescentAdultAnalysis of VarianceArteriosclerosisBlood GlucoseCarotid Artery, CommonCarotid Artery DiseasesCase-Control StudiesDiabetes Mellitus, Type 1Disease ProgressionFemaleFollow-Up StudiesHumansLeast-Squares AnalysisLinear ModelsLipidsBlood GlucoseLipids

Identifiers

PMID12788993
PMCPMC2701300

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.