Evidence map›Paper›PMID 12788841›Full record

ReviewThe Journal of clinical endocrinology and metabolism2003

Pharmacological therapy of obesity: past, present, and future.

David S Weigle

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of clinical endocrinology and metabolism, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00941382 (Double-blind, Randomized Clinical Trial to Evaluate Effect of Combination Therapy of Metformin and Sibutramine Versus Metformin or Sibutramine Monotherapy Over Weight, Adiposity, Glucose Metabolism and Inflammatory State in Obese Patients), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00941382 phase3unknown statusstarted 2008, after this paper: background citation

Double-blind, Randomized Clinical Trial to Evaluate Effect of Combination Therapy of Metformin and Sibutramine Versus Metformin or Sibutramine Monotherapy Over Weight, Adiposity, Glucose Metabolism and Inflammatory State in Obese Patients

Ran2008Enrolled60Registered outcomes3Posted comparisons0ConditionsObesityArmsMetformin, Sibutramine, Sibutramine-Metformin
Open the trial in the graph
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Anti-adipogenic effect ofFood science and biotechnology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Anti-Obesity Effect of Extract fromFoods (Basel, Switzerland) · 2019
    Article
  12. Review
  13. Weighing in on bariatric surgery: who and when?International journal of obesity supplements · 2012
    Article
  14. Inhibitory effects of corni fructus extract on angiogenesis and adipogenesis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2011
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Current and novel approaches to the drug therapy of obesity.European journal of clinical pharmacology · 2006
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David S WeigleEndocrinology, University of Washington School of Medicine and Harborview Medical Center, Seattle, Washington 98104, USA. weigle@u.washington.edu

Funding

METABOLIC CONSEQUENCES OF ANTIRETROVIRAL THERAPYR01DK055460 · NIDDK · UNIVERSITY OF WASHINGTON · PI WEIGLE, DAVID S · 1999 to 2003
$1.8M
STUDIES OF REGIONAL FAT DISTRIBUTION AND ENERGY BALANCEK24DK002860 · NIDDK · UNIVERSITY OF WASHINGTON · PI WEIGLE, DAVID S · 2001 to 2005
$486k
NIDDK NIH HHS DK02860NIDDK NIH HHS DK55460
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Obesity AgentsAppetite DepressantsCyclobutanesEndocrinologyHumansLactonesObesityOrlistatAnti-Obesity AgentsAppetite DepressantsCyclobutanesLactonesOrlistatsibutramine

Identifiers

PMID12788841

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.