ArticleTrends in biotechnology2003
Synthetic gene libraries: in search of the optimal diversity.
Article in Trends in biotechnology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Computational and experimental engineering of aFood chemistry: X · 2026Article
- Rationally modified estrogen receptor protein as a bio-recognition element for the detection of EDC pollutants: strategies and opportunities.International journal of environmental research and public health · 2015Article
- Targeting the active site gate to yield hyperactive variants of 5-aminolevulinate synthase.The Journal of biological chemistry · 2010Article
- On the conservative nature of intragenic recombination.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- FamClash: a method for ranking the activity of engineered enzymes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
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1 author.
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Abstract
Directed evolution has proven to be an effective method for evolving proteins with desired properties. A key step is the creation of suitably diverse gene libraries. Two new methods for creating such libraries make sole use of synthesized oligonucleotides and allow researchers to tailor the diversity of a library with greater precision and create libraries with greater diversity than was previously possible. Such increased diversity appears to accelerate directed evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.