ReviewAdvanced drug delivery reviews2003
Emerging significance of plasmid DNA nuclear import in gene therapy.
Review in Advanced drug delivery reviews, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Modification of the tumor microenvironment enhances immunity with plasmid gene therapy.Cancer gene therapy · 2024Article
- Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023Review
- Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase.Communications biology · 2022Article
- Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization.Pharmaceutics · 2020Review
- Photosensitive Poly-l-lysine/Heparin Interpolyelectrolyte Complexes for Delivery of Genetic Drugs.Polymers · 2020Article
- Article
- Properties of internalization factors contributing to the uptake of extracellular DNA into tumor-initiating stem cells of mouse Krebs-2 cell line.Stem cell research & therapy · 2016Article
- Insight concerning the mechanism of therapeutic ultrasound facilitating gene delivery: increasing cell membrane permeability or interfering with intracellular pathways?Human gene therapy · 2014Article
- Membrane and nuclear permeabilization by polymeric pDNA vehicles: efficient method for gene delivery or mechanism of cytotoxicity?Molecular pharmaceutics · 2012Article
- PEGylation improves nanoparticle formation and transfection efficiency of messenger RNA.Pharmaceutical research · 2011Article
- Identification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import.The Journal of biological chemistry · 2009Article
- Maintaining the silence: reflections on long-term RNAi.Drug discovery today · 2008Review
- Terminal proteins of Streptomyces chromosome can target DNA into eukaryotic nuclei.Nucleic acids research · 2008Article
- Efficient gene transfer in CLL by mRNA electroporation.Leukemia · 2008Article
- Gene-enhanced tissue engineering for dental hard tissue regeneration: (1) overview and practical considerations.Head & face medicine · 2006Article
- Noncovalently linked nuclear localization peptides for enhanced calcium phosphate transfection.Molecular biotechnology · 2006Article
- Role for centromeric heterochromatin and PML nuclear bodies in the cellular response to foreign DNA.Molecular and cellular biology · 2006Article
- The nuclear pore complex: the gateway to successful nonviral gene delivery.Pharmaceutical research · 2006Review
- Therapeutic ultrasound-mediated DNA to cell and nucleus: bioeffects revealed by confocal and atomic force microscopy.Gene therapy · 2006Article
- Tracking of microinjected DNA in live cells reveals the intracellular behavior and elimination of extrachromosomal genetic material.Nucleic acids research · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The signal-mediated import of plasmid DNA (pDNA) into nondividing mammalian cell nuclei is one of the key biological obstacles to nonviral therapeutic pDNA delivery. Overcoming this barrier to pDNA transfer is thus an important fundamental objective in gene therapy. Here, we outline the rationale behind current and future strategies for signal-mediated pDNA nuclear import. Results obtained from studies of the nuclear delivery of pDNA coupled to experimentally defined nuclear localisation signal (NLS) peptides, in conjunction with detergent-permeabilised reconstitution cell assays, direct intracellular microinjection, cell-based transfection, and a limited number of in vivo experiments are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.