ReviewJournal of muscle research and cell motility2002
Mechanical response of single filamin A (ABP-280) molecules and its role in the actin cytoskeleton.
Review in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Unraveling the pathogenic mechanism of a novel filamin a frameshift variant in periventricular nodular heterotopia.Frontiers in pharmacology · 2024Article
- Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface.International journal of molecular sciences · 2021Review
- A biophysical perspective on receptor-mediated virus entry with a focus on HIV.Biochimica et biophysica acta. Biomembranes · 2020Review
- Microtubules: Evolving roles and critical cellular interactions.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- The role of membrane tension in the action of antimicrobial peptides and cell-penetrating peptides in biomembranes.Biophysical reviews · 2019Review
- Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation.Stem cells international · 2019Review
- Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins.Molecular biology of the cell · 2018Article
- Mechanical dynamics in live cells and fluorescence-based force/tension sensors.Biochimica et biophysica acta · 2015Review
- Two fundamental mechanisms govern the stiffening of cross-linked networks.Biophysical journal · 2015Article
- Article
- Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells.Journal of cell science · 2012Article
- Filamins in mechanosensing and signaling.Annual review of biophysics · 2012Review
- Filamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?Biophysical reviews · 2011Review
- Article
- Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells.Investigative ophthalmology & visual science · 2010Article
- Molecular origin of strain softening in cross-linked F-actin networks.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- In-frame deletion in the seventh immunoglobulin-like repeat of filamin C in a family with myofibrillar myopathy.European journal of human genetics : EJHG · 2009Article
- Measuring molecular rupture forces between single actin filaments and actin-binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Molecular mechanics of filamin's rod domain.Biophysical journal · 2008Article
- Biological roles of filamin a in prostate cancer cells.International braz j urol : official journal of the Brazilian Society of UrologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamin A produces isotropic cross-linked three-dimensional orthogonal networks with actin filaments in the cortex and at the leading edge of cells. Filamin A also links the actin cytoskeleton to the plasma membrane via its association with various kinds of membrane proteins. Recent new findings strongly support that filamin A plays important roles in the mechanical stability of plasma membrane and cortex, formation of cell shape, mechanical responses of cells, and cell locomotion. To elucidate the mechanical properties of the actin/filamin A network and the complex of membrane protein-filamin A-actin cytoskeleton, the mechanical properties of single human filamin A (hsFLNa) molecules in aqueous solution were investigated using atomic force microscopy. Ig-fold domains of filamin A can be unfolded by the critical external force (50-220 pN), and this unfolding is reversible, i.e., the refolding of the unfolded chain of the filamin A occurs when the external force is removed. Due to this reversible unfolding of Ig-fold domains, filamin A molecule can be stretched to several times the length of its native state. Based on this new feature of filamin A as the 'large-extensible linker', we describe our hypothesis for the mechanical role of filamin A in the actin cytoskeletons in cells and discuss its biological implications. In this review, function of filamin A in actin cytoskeleton, mechanical properties of single filamin A proteins, and the hypothesis for the mechanical role of filamin A in the actin cytoskeletons are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.