ReviewJournal of muscle research and cell motility2002
Titin as a modular spring: emerging mechanisms for elasticity control by titin in cardiac physiology and pathophysiology.
Review in Journal of muscle research and cell motility, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Simple and Practical Way of Assessing Diastolic Function: Diastolic Heart Failure Revisited.Korean circulation journal · 2025Review
- Mechanism-based myofilament manipulation to treat diastolic dysfunction in HFpEF.Frontiers in physiology · 2024Review
- The contribution of N-terminal truncated cMyBPC to in vivo cardiac function.The Journal of general physiology · 2023Article
- Cardiac Sarcomere Signaling in Health and Disease.International journal of molecular sciences · 2022Review
- High hydrostatic pressure induces slow contraction in mouse cardiomyocytes.Biophysical journal · 2022Article
- Interaction of chloramphenicol with titin I27 probed using single-molecule force spectroscopy.Journal of biological physics · 2021Article
- Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.Basic research in cardiology · 2021Article
- Training Induced Changes to Skeletal Muscle Passive Properties Are Evident in Both Single Fibers and Fiber Bundles in the Rat Hindlimb.Frontiers in physiology · 2020Article
- Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity.The Journal of general physiology · 2019Article
- The multiple roles of titin in muscle contraction and force production.Biophysical reviews · 2018Review
- From stem cells to cardiomyocytes: the role of forces in cardiac maturation, aging, and disease.Progress in molecular biology and translational science · 2014Review
- Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium.European biophysics journal : EBJ · 2013Article
- N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle.The Journal of physiology · 2013Article
- Muscle giants: molecular scaffolds in sarcomerogenesis.Physiological reviews · 2009Review
- Xtn3 is a developmentally expressed cardiac and skeletal muscle-specific novex-3 titin isoform.Gene expression patterns : GEP · 2006Article
- Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.Molecular biology of the cell · 2006Article
- In indirect flight muscles Drosophila projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band.Journal of muscle research and cell motility · 2005Article
- Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The role of unstructured extensions in the rotational diffusion properties of a globular protein: the example of the titin i27 module.Biophysical journal · 2004Article
- Maternal nutrient restriction alters gene expression in the ovine fetal heart.The Journal of physiology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Titin is a giant elastic protein that functions as a molecular spring that develops passive muscle stiffness. Here we discuss the molecular basis of titin's extensibility, how titin's contribution to passive muscle stiffness may be adjusted and how adjustment of titin's stiffness may influence muscle contraction. We also focus on ligands that link titin to membrane channel activity, protein turnover and gene expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.