ArticleJournal of clinical pathology2003
Digital slide and virtual microscopy based routine and telepathology evaluation of routine gastrointestinal biopsy specimens.
Article in Journal of clinical pathology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center.Archives of pathology & laboratory medicine · 2013Guideline
- Observer variability in the interpretation of HER2/neu immunohistochemical expression with unaided and computer-aided digital microscopy.Archives of pathology & laboratory medicine · 2011Trial
- Virtual Microscopy Goes Global: The Images Are Virtual and the Problems Are Real.Advances in experimental medicine and biology · 2023Article
- Digital slide viewing for primary reporting in gastrointestinal pathology: a validation study.Virchows Archiv : an international journal of pathology · 2015Article
- Comparison of the manual, semiautomatic, and automatic selection and leveling of hot spots in whole slide images for Ki-67 quantification in meningiomas.Analytical cellular pathology (Amsterdam) · 2015Article
- Intra-observer reproducibility of whole slide imaging for the primary diagnosis of breast needle biopsies.Journal of pathology informatics · 2014Article
- Observer performance in the use of digital and optical microscopy for the interpretation of tissue-based biomarkers.Analytical cellular pathology (Amsterdam) · 2014Article
- Validation of a whole slide imaging system for primary diagnosis in surgical pathology: A community hospital experience.Journal of pathology informatics · 2014Article
- Evaluation of mitotic activity index in breast cancer using whole slide digital images.PloS one · 2013Article
- Improving international research with clinical specimens: 5 achievable objectives.Journal of proteome research · 2012Article
- Validation of diagnostic accuracy using digital slides in routine histopathology.Diagnostic pathology · 2012Article
- Robust segmentation of overlapping cells in histopathology specimens using parallel seed detection and repulsive level set.IEEE transactions on bio-medical engineering · 2012Article
- Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases.British journal of cancer · 2011Article
- Quantification of virtual slides: Approaches to analysis of content-based image information.Journal of pathology informatics · 2011Article
- Barriers and facilitators to adoption of soft copy interpretation from the user perspective: Lessons learned from filmless radiology for slideless pathology.Journal of pathology informatics · 2011Article
- Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations.Archives of pathology & laboratory medicine · 2009Article
- Virtual slide telepathology workstation of the future: lessons learned from teleradiology.Human pathology · 2009Article
- A European network for virtual microscopy--design, implementation and evaluation of performance.Virchows Archiv : an international journal of pathology · 2009Article
- Theory of sampling and its application in tissue based diagnosis.Diagnostic pathology · 2009Article
- Image standards in tissue-based diagnosis (diagnostic surgical pathology).Diagnostic pathology · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate a recently developed digital slide and virtual microscope system, and to compare this method with optical microscopy on routine gastrointestinal biopsy specimens in both local and remote access modes.
methodsA fully computer controlled commercial microscope was used. The scanning program included object detection, autofocus, and image compression algorithms. The overall hard disk space for a gastric biopsy was between 30 and 50 MB and the scanning time was between 20 and 40 minutes. Haematoxylin and eosin stained routine gastric (61) and colon (42) biopsy specimens were selected, scanned, and evaluated by two specialists on an optical (OM) and virtual microscope (VM).
resultsThe overall concordance of VM and OM with the consensus diagnosis was 95.1% and 97%, respectively. Clinically important concordance was 96.1% and 98% for VM and OM, respectively. The two methods showed concordance in 92% of cases and clinically important concordance in 94.1% of cases. The reasons for discordance were image quality (one case), interpretation difference (three cases), and insufficient clinical information (three cases). Remote evaluation of the digital slides through the Internet has the advantages of the previously used static and dynamic telepathology methods.
conclusionsDiagnostic concordance was found between OM and VM. The digital slide and the virtual microscope can be alternative techniques in the computerisation of the histology laboratory and in teleconsultation services after further evaluation of time and storage constraints.
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