ArticleHuman genetics2003
Markers informative for ancestry demonstrate consistent megabase-length linkage disequilibrium in the African American population.
Article in Human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.Ophthalmology · 2019Article
- Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM).Molecular genetics & genomic medicine · 2017Article
- Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel.Investigative genetics · 2013Article
- Human population admixture in Asia.Genomics & informatics · 2012Article
- Race as a social construct in head and neck cancer outcomes.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2011Article
- Analyses of a set of 128 ancestry informative single-nucleotide polymorphisms in a global set of 119 population samples.Investigative genetics · 2011Article
- An admixture scan in 1,484 African American women with breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Article
- An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans.PLoS genetics · 2009Article
- Analysis of genomic admixture in Uyghur and its implication in mapping strategy.American journal of human genetics · 2008Article
- Estimating local ancestry in admixed populations.American journal of human genetics · 2008Article
- Austronesian genetic signature in East African Madagascar and Polynesia.Journal of human genetics · 2008Article
- Sample matching by inferred agonal stress in gene expression analyses of the brain.BMC genomics · 2007Article
- A genomewide admixture map for Latino populations.American journal of human genetics · 2007Article
- Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.American journal of human genetics · 2007Article
- A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping.American journal of human genetics · 2006Article
- Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.American journal of respiratory cell and molecular biology · 2006Article
- Admixture mapping as a gene discovery approach for complex human traits and diseases.Current hypertension reports · 2005Review
- Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping.Genome research · 2004Article
- A high-density admixture map for disease gene discovery in african americans.American journal of human genetics · 2004Article
- Methods for high-density admixture mapping of disease genes.American journal of human genetics · 2004Article
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5 authors.
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Abstract
Admixture mapping is a potentially powerful tool for mapping complex genetic diseases. For application of this method, admixed individuals must have genomes composed of large segments derived intact from each founding population. Such segments are thought to be present in African Americans (AA) and should be demonstrable by examination of linkage disequilibrium (LD). Previous studies using a variety of polymorphic markers have variably reported long-range LD or rapid decay of LD. To further define the extent and characteristics of LD caused by admixture in the AA population, the current study utilized a set of 52 diallelic markers that were selected for large standard variances between putative representatives of the founder populations. LD was examined in over 250 marker-pairs, including linked markers from four different chromosomal regions and an equal number of matched unlinked comparisons. In the representative founder populations, strong LD was not observed for markers separated by more than 10 kb. In contrast, results indicated significant LD ( P<0.001, D'>0.3) in AA over large genomic segments exceeding 10 centiMorgans (cM) and 15 megabases (Mb). Only marginally significant LD was present between unlinked markers in this population, suggesting that choosing appropriate levels of significance for admixture mapping can minimize false positive results. The ability to detect LD for extended chromosomal segments in AA decayed not only as a function of the distance between markers, but also as a function of the standard variance of the markers. This examination of several genomic segments provides strong evidence that appropriate selection of informative markers is a crucial prerequisite for the application of admixture mapping to the AA population.
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