ArticleIntensive care medicine2003
Oxidative parameters and mortality in sepsis induced by cecal ligation and perforation.
Article in Intensive care medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 195 citations in OpenAlex.
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- Ayahuasca Pretreatment Prevents Sepsis-Induced Anxiety-Like Behavior, Neuroinflammation, and Oxidative Stress, and Increases Brain-Derived Neurotrophic Factor.Molecular neurobiology · 2025Article
- Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathy.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Nanoemulsions and nanocapsules loaded with Melaleuca alternifolia essential oil for sepsis treatment.Drug delivery and translational research · 2024Article
- Oxidative damage in the gastrocnemius predicts long-term survival in patients with peripheral artery disease.npj aging · 2024Article
- Modulating Nrf-2/HO-1, apoptosis and oxidative stress signaling pathways by gabapentin ameliorates sepsis-induced acute kidney injury.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Nicotinamide Riboside Preserves Ovarian Injury in Experimental Sepsis Model in Rats.The Eurasian journal of medicine · 2023Article
- Inhibition of SHP2 by the Small Molecule Drug SHP099 Prevents Lipopolysaccharide-Induced Acute Lung Injury in Mice.Inflammation · 2023Article
- Potential therapeutic effect of3 Biotech · 2023Article
- Mechanism of Action of Natural Compounds in Peripheral Multiorgan Dysfunction and Hippocampal Neuroinflammation Induced by Sepsis.Antioxidants (Basel, Switzerland) · 2023Article
- Effects of adenosine N1-Oxide and pioglitazone on inflammatory and antioxidant state in sepsis caused by experimental cecal puncture in rat.Veterinary research forum : an international quarterly journal · 2023Article
- Neuropeptide W Attenuates Oxidative Multi-Organ Injury in Rats Induced with Intra-Abdominal Sepsis.Inflammation · 2022Article
- Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways.Antioxidants (Basel, Switzerland) · 2021Review
- Glutathione Reductase Is Associated with the Clinical Outcome of Septic Shock in the Patients Treated Using Continuous Veno-Venous Haemofiltration.Medicina (Kaunas, Lithuania) · 2021Observational
- Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.Molecular neurobiology · 2020Article
- HDAC6 promotes sepsis development by impairing PHB1-mediated mitochondrial respiratory chain function.Aging · 2020Article
- Stratification to predict the response to antioxidant.Revista Brasileira de terapia intensiva · 2020Article
- Hypothermia Effects on Liver and Kidney Oxidative Stress Parameters in an Experimental Model of Sepsis in Rats.Journal of veterinary research · 2020Article
- Anti-inflammatory Effects of Deuterium-Depleted Water PlusTurkish journal of pharmaceutical sciences · 2020Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study assessed parameters of free radical damage to biomolecules, mitochondrial superoxide production, superoxide dismutase, and catalase activities and their relationship to sepsis mortality. DESIGN AND
settingProspective animal study in a university laboratory for experimental. SUBJECTS: 140 male Wistar rats.
interventionsThe animals were randomly divided into three groups: sham-operated (n=20), cecal ligation and perforation resuscitated with normal saline (n=40), and cecal ligation and perforation with normal saline plus antibiotics (n=40). MEASUREMENTS AND
resultsBlood samples were collected from all animals 3, 12, and 24 h after CLP through a jugular catheter inserted before CLP. Rats were evaluated during 5 days after the intervention. Nonsurvivor animals were grouped according to the duration between sepsis induction and death, and oxidative parameters were compared to survivors and sham-operated. Lipid peroxidation, protein carbonyls, and superoxide dismutase were significantly increased in nonsurvivor septic rats and were predictive of mortality. We demonstrated that there is a different modulation of superoxide dismutase and catalase in nonsurvivors during the course of septic response. There was a marked increase in superoxide dismutase activity without a proportional increase in catalase activity in nonsurvivors.
conclusionsThis is the first report of plasma superoxide dismutase as an earlier marker of mortality. Ours results might help to clarify an important aspect of oxidative response to sepsis, i.e., an increase in superoxide dismutase activity without a proportional increase in catalase activity
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.