ArticleThe Journal of experimental medicine2003
Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis.
Article in The Journal of experimental medicine, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 78 citations in OpenAlex.
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- Is Cadmium Genotoxicity Due to the Induction of Redox Stress and Inflammation? A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Cytokine Kinetics during Progression of COVID-19 in Rwanda Patients: Could IL-9/IFNγ Ratio Predict Disease Severity?International journal of molecular sciences · 2023Article
- The relationship between peripheral immune response and disease severity in SARS-CoV-2-infected subjects: A cross-sectional study.Immunology · 2022Article
- Macrophage Boolean networks in the time of SARS-CoV-2.Frontiers in immunology · 2022Article
- B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction.Cell death & disease · 2021Article
- Elevated Interleukin-10 Levels in COVID-19: Potentiation of Pro-Inflammatory Responses or Impaired Anti-Inflammatory Action?Frontiers in immunology · 2021Article
- Promotion of macrophage activation by Tie2 in the context of the inflamed synovia of rheumatoid arthritis and psoriatic arthritis patients.Rheumatology (Oxford, England) · 2020Article
- Granulocyte-macrophage colony-stimulating factor negatively regulates early IL-10-mediated responses.Future science OA · 2018Article
- Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States.Frontiers in physiology · 2018Article
- Association of IL-10 gene (-1082A>G, -819C>T and -592C>A) polymorphism and its serum level with metabolic syndrome of north Indian subjects.Journal of genetics · 2017Article
- Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.Scientific reports · 2016Article
- Control of cytokine production by human fc gamma receptors: implications for pathogen defense and autoimmunity.Frontiers in immunology · 2015Review
- Interleukin-10 attenuation of collagen-induced arthritis is associated with suppression of interleukin-17 and retinoid-related orphan receptor γt production in macrophages and repression of classically activated macrophages.Arthritis research & therapy · 2014Article
- The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment.Arthritis and rheumatism · 2012Article
- Soluble immune complexes shift the TLR-induced cytokine production of distinct polarized human macrophage subsets towards IL-10.PloS one · 2012Article
- Article
- Systemic lupus erythematosus monocytes are less responsive to interleukin-10 in the presence of immune complexes.Arthritis and rheumatism · 2011Article
- Macrophages in synovial inflammation.Frontiers in immunology · 2011Article
- Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase.PloS one · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Interleukin-10 (IL-10) is a potent deactivator of myeloid cells that limits the intensity and duration of immune and inflammatory responses. The activity of IL-10 can be suppressed during inflammation, infection, or after allogeneic tissue transplantation. We investigated whether inflammatory factors suppress IL-10 activity at the level of signal transduction. Out of many factors tested, only ligation of Fc receptors by immune complexes inhibited IL-10 activation of the Jak-Stat signaling pathway. IL-10 signaling was suppressed in rheumatoid arthritis joint macrophages that are exposed to immune complexes in vivo. Activation of macrophages with interferon-gamma was required for Fc receptor-mediated suppression of IL-10 signaling, which resulted in diminished activation of IL-10-inducible genes and reversal of IL-10-dependent suppression of cytokine production. The mechanism of inhibition involved decreased cell surface IL-10 receptor expression and Jak1 activation and was dependent on protein kinase C delta. These results establish that IL-10 signaling is regulated during inflammation and identify Fc receptors and interferon-gamma as important regulators of IL-10 activity. Generation of macrophages refractory to IL-10 can contribute to pathogenesis of inflammatory and infectious diseases characterized by production of interferon-gamma and immune complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.