ArticleClinical and experimental immunology2003
Staphylococcal superantigens and T cell expansions in Wegener's granulomatosis.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- The Influence and Role of Microbial Factors in Autoimmune Kidney Diseases: A Systematic Review.Journal of immunology research · 2015Pooled it
- Co-trimoxazole and prevention of relapses of PR3-ANCA positive vasculitis with pulmonary involvement.European journal of medical research · 2009Trial
- Pediatric-onset limited ANCA-associated vasculitis arising during pre-existing chronic recurrent multifocal osteomyelitis.Pediatric rheumatology online journal · 2023Article
- Anti-staphylococcal responses and their relationship with HLA-DR-DQ polymorphism in granulomatosis with polyangiitis: a preliminary evidence of association with disease outcome.Clinical and experimental medicine · 2023Article
- Nasal microbiome research in ANCA-associated vasculitis: Strengths, limitations, and future directions.Computational and structural biotechnology journal · 2021Review
- Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides.Scientific reports · 2017Article
- Chemokine receptor co-expression reveals aberrantly distributed TArthritis research & therapy · 2017Article
- Gut microbiome and kidney disease: a bidirectional relationship.Pediatric nephrology (Berlin, Germany) · 2017Review
- Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure.Scientific reports · 2015Article
- Pathophysiological Relationship between Infections and Systemic Vasculitis.Autoimmune diseases · 2015Review
- The immunopathology of ANCA-associated vasculitis.Seminars in immunopathology · 2014Review
- Myeloperoxidase-antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis in autosomal dominant polycystic kidney disease.BMC nephrology · 2013Article
- Glomerular disease in patients with infectious processes developing antineutrophil cytoplasmic antibodies.ISRN nephrology · 2013Review
- Pathogenesis of ANCA-associated vasculitis.Current rheumatology reports · 2012Review
- Classification of antineutrophil cytoplasmic autoantibody vasculitides: the role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis.Arthritis and rheumatism · 2012Article
- Pathogenesis of ANCA-associated vasculitis, an update.Clinical reviews in allergy & immunology · 2011Review
- Pathogenesis of ANCA-associated vasculitis.Rheumatic diseases clinics of North America · 2010Review
- Analysis of T-cell receptor usage in myeloperoxidase--antineutrophil cytoplasmic antibody-associated renal vasculitis.Clinical and experimental nephrology · 2010Article
- Infection and vasculitis.Rheumatology (Oxford, England) · 2009Review
- Vasculitis and infections: contribution to the issue of autoimmunity reviews devoted to "autoimmunity and infection".Autoimmunity reviews · 2008Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Wegener's granulomatosis (WG), a form of autoimmune systemic vasculitis, chronic carriage of Staphylococcus aureus constitutes a risk factor for the development of exacerbations. Circulating T cells in this disease are persistently activated, suggesting the presence of a chronic stimulus. A causal link between chronic carriage of S. aureus and chronic T cell activation in WG is conceivable, because S. aureus produces superantigens (SAg), which are potent T cell stimulators. Superantigenic stimulation of T cells results in expansion of T cell subsets expressing SAg-binding T cell receptor V-beta (Vbeta) chains. In the present study we hypothesized that in WG the presence of staphylococcal SAg is accompanied by expansion of SAg-reacting T cell subsets. We tested our hypothesis in a cross-sectional and a longitudinal study in which the association between seven staphylococcal SAg genes [typed by poplymerase chain reaction (PCR)], eight SAg-binding Vbeta chains and four SAg-non-binding Vbeta chains (assessed by flow-cytometry) was assessed. Both studies showed that T cell expansions were present at a significantly higher rate in WG patients than in healthy individuals, but were not associated with the presence of either S. aureus or its SAg. Moreover, T cell expansions were generally of small extent, and did not appear simultaneously in both CD4 and CD8 subsets. We conclude that in WG S. aureus effects its supposed pathogenic function by a mechanism other than superantigenic T cell activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.