ArticleClinical and experimental immunology2003
Release of endogenous anti-inflammatory complement regulators FHL-1 and factor H protects synovial fibroblasts during rheumatoid arthritis.
Article in Clinical and experimental immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation.Scientific reports · 2025Article
- Transcriptional Analysis Reveals That the FHL1/JAK-STAT Pathway is Involved in Acute Cartilage Injury in Mice.Cartilage · 2025Article
- Complement factor H in molecular regulation of angiogenesis.Medical review (2021) · 2024Review
- In Vitro Investigation of Pulsed Electromagnetic Field Stimulation (PEMF) with MAGCELLJournal of personalized medicine · 2024Article
- Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear.Frontiers in immunology · 2023Article
- Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic biomarkers.Frontiers in immunology · 2023Article
- Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions.Frontiers in immunology · 2020Review
- Identification of potential serum biomarkers for rheumatoid arthritis by high-resolution quantitative proteomic analysis.Inflammation · 2014Article
- Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Properdin and factor h: opposing players on the alternative complement pathway "see-saw".Frontiers in immunology · 2013Article
- c-Jun and c-Fos regulate the complement factor H promoter in murine astrocytes.Molecular immunology · 2011Article
- Mesenchymal stem cells inhibit complement activation by secreting factor H.Stem cells and development · 2010Article
- Article
- The C-terminus of complement factor H is essential for host cell protection.Molecular immunology · 2007Article
- Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site.The American journal of pathology · 2005Article
- Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group A streptococci.Infection and immunity · 2003Article
- Polysomnographic correlates of inflammatory complement components in young healthy males.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis is a chronic inflammatory disease of unknown aetiology predominantly affecting cells and tissues of synovial joints. Here we show that the two important complement regulators FHL-1 and factor H play a protective anti-inflammatory role in rheumatoid arthritis. Expression analyses at the mRNA- and protein level show in vitro expression and secretion of both regulators by synovial fibroblasts derived from patients with rheumatoid arthritis. Similarly the two regulators are synthesized in vivo in diseased synovial tissue, and in particular synovial lining cells express high levels of FHL-1. The anti-inflammatory role of these regulators in rheumatoid arthritis is highlighted by their induction with IFN-gamma and dexamethasone, whilst the pro-inflammatory cytokine TNF-alpha had no effect. Transient transfection experiments with various FHL-1/factor H promoter-luciferase reporter constructs into cells of distinct origin show independent cell and tissue specific promoter regulated transcription of these two regulators. The inducible expression, specifically of FHL-1 has physiological consequences. By binding directly to surfaces the released proteins protect cells from inflammatory damage and complement-mediated cell lysis. This study shows a novel protective and anti-inflammatory role of the two important complement regulators FHL-1 and factor H in rheumatoid arthritis and suggests a disease controlling role of the two proteins.
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