ArticleTransgenic research2003
Placental anomalies and fetal loss in mice, after administration of doxycycline in food for tet-system activation.
Article in Transgenic research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Progressive cardiac phenotypes and reduced reversibility from long-term CUGexp RNA expression in a DM1 mouse model.JCI insight · 2026Article
- Sterilization of Channel Catfish (Ictalurus punctatus) via Overexpression of bax Gene Regulated by a Tet-off System in the Primordial Germ Cells.Marine biotechnology (New York, N.Y.) · 2025Article
- The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A safety guide for transgenic Cre drivers in metabolism.Nature metabolism · 2024Article
- RuX: A Novel, Flexible, and Sensitive Mifepristone-Induced Transcriptional Regulation System.International journal of cell biology · 2023Article
- Perinatal exposure to tetracycline contributes to lasting developmental effects on offspring.Animal microbiome · 2021Article
- Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Nicotine protects fetus against LPS-induced fetal growth restriction through ameliorating placental inflammation and vascular development in late pregnancy in rats.Bioscience reports · 2019Article
- Transmission of microRNA antimiRs to mouse offspring via the maternal-placental-fetal unit.RNA (New York, N.Y.) · 2018Article
- Use of antibiotics during pregnancy and the risk of major congenital malformations: a population based cohort study.British journal of clinical pharmacology · 2017Article
- A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development.Oncotarget · 2017Article
- Use of antibiotics during pregnancy and risk of spontaneous abortion.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017Article
- Stability of Doxycycline in Feed and Water and Minimal Effective Doses in Tetracycline-Inducible Systems.Journal of the American Association for Laboratory Animal Science : JAALAS · 2016Article
- An independent construct for conditional expression of atonal homolog-1.Human gene therapy methods · 2014Article
- Transient, inducible, placenta-specific gene expression in mice.Endocrinology · 2012Article
- Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction.Journal of the American Heart Association · 2012Article
- Genetically manipulated mouse models of lung disease: potential and pitfalls.American journal of physiology. Lung cellular and molecular physiology · 2012Review
- Antibiotics potentially used in response to bioterrorism and the risk of major congenital malformations.Paediatric and perinatal epidemiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the course of a study aiming to obtain a tetracycline (Tet)-inducible transgene expression restricted to the placenta, we have observed a toxicity of doxycycline (dox) given in the food at doses of 2.5-10 mg/g to pregnant mice from two different inbred strains. During the second half of gestation, dox-fed non-transgenic mice presented placental anomalies and impaired fetal development proportional to the dose of antibiotic. Thus, dox administered in commonly used food doses can have an adverse effect on pregnancy. These observations are important for studies of placental or fetal development using inducible gene promoters.
Indexed as
Identifiers
12779125What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.