ReviewMolecular neurobiology2003
Visualizing activation of opioid circuits by internalization of G protein-coupled receptors.
Review in Molecular neurobiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
- The Phytoestrogenic Effect of Hibiscus sabdariffa Involves Estrogen Receptor α in Ovariectomized Wistar Rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023Article
- Membrane estrogen signaling in female reproduction and motivation.Frontiers in endocrinology · 2022Review
- Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity.Hormones and behavior · 2018Review
- Estradiol Membrane-Initiated Signaling in the Brain Mediates Reproduction.Trends in neurosciences · 2017Review
- Integrating Neural Circuits Controlling Female Sexual Behavior.Frontiers in systems neuroscience · 2017Review
- Sexually-motivated song is predicted by androgen-and opioid-related gene expression in the medial preoptic nucleus of male European starlings (Sturnus vulgaris).Behavioural brain research · 2015Article
- The effects of beta-endorphin: state change modification.Fluids and barriers of the CNS · 2015Review
- Membrane-initiated non-genomic signaling by estrogens in the hypothalamus: cross-talk with glucocorticoids with implications for behavior.Frontiers in endocrinology · 2015Review
- Article
- Temporal and concentration-dependent effects of oestradiol on neural pathways mediating sexual receptivity.Journal of neuroendocrinology · 2013Review
- Modulation of the arcuate nucleus-medial preoptic nucleus lordosis regulating circuit: a role for GABAB receptors.Hormones and behavior · 2013Article
- Fluorescently-Labeled Estradiol Internalization and Membrane Trafficking in Live N-38 Neuronal Cells Visualized with Total Internal Reflection Fluorescence Microscopy.Journal of steroids & hormonal science · 2013Article
- Estradiol signaling in the regulation of reproduction and energy balance.Frontiers in neuroendocrinology · 2012Review
- Membrane-initiated estradiol signaling regulating sexual receptivity.Frontiers in endocrinology · 2011Article
- The Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge.Frontiers in endocrinology · 2011Article
- Estradiol rapidly regulates membrane estrogen receptor alpha levels in hypothalamic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Estrogen actions on neuroendocrine glia.Neuroendocrinology · 2010Article
- Membrane estradiol signaling in the brain.Frontiers in neuroendocrinology · 2009Review
- Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology.Steroids · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mu-opioid receptor (MOR) and opioid receptor-like receptor (ORL-1) circuits in the limbic hypothalamic system are important for the regulation of sexual receptivity in the female rat. Sexual receptivity is tightly regulated by the sequential release of estrogen and progesterone from the ovary suggesting ovarian steroids regulate the activity of these neuropeptide systems. Both MOR and ORL-1 distributions overlap with the distribution of estrogen and progesterone receptors in the hypothalamus and limbic system providing a morphological substrate for interaction between steroids and the opioid circuits in the brain. Both MOR and ORL-1 are receptors that respond to activation by endogenous ligands with internalization into early endosomes. This internalization is part of the mechanism of receptor desensitization or down regulation. Although receptor activation and internalization are separate events, internalization can be used as a temporal measure of circuit activation by endogenous ligands. This review focuses on the estrogen and progesterone regulation of MOR and ORL-1 circuits in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus that are central to modulating sexual receptivity.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.