ReviewMolecular neurobiology2003
Regulation of neuronal proliferation and differentiation by nitric oxide.
Review in Molecular neurobiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response.Current neuropharmacology · 2020Pooled it
- A specific, non-immune system-related isoform of the human inducible nitric oxide synthase is expressed during differentiation of human stem cells into various cell types.Cell communication and signaling : CCS · 2022Article
- Nitric oxide and the brain. Part 1: Mechanisms of regulation, transport and effects on the developing brain.Pediatric research · 2021Review
- L-Arginine Exerts Excellent Anti-Stress Effects on Stress-Induced Shortened Lifespan, Cognitive Decline and Depression.International journal of molecular sciences · 2021Article
- TRPC5 regulates axonal outgrowth in developing retinal ganglion cells.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Prenatal Nicotine Exposure Disrupts Infant Neural Markers of Orienting.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Article
- Roles of Nitric Oxide Synthase Isoforms in Neurogenesis.Molecular neurobiology · 2018Review
- Development of a reactive oxygen species-sensitive nitric oxide synthase inhibitor for the treatment of ischemic stroke.Free radical biology & medicine · 2018Article
- Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions.Neural plasticity · 2018Review
- A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression.Scientific reports · 2015Article
- Ontogenesis of NADPH-diaphorase positive neurons in guinea pig neocortex.Frontiers in neuroanatomy · 2015Article
- Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects.Frontiers in physiology · 2015Review
- Effects of nitric oxide modulating activities on development of enteric nervous system mediated gut motility in chick embryo model.Journal of biosciences · 2014Article
- Kinin-B2 receptor activity determines the differentiation fate of neural stem cells.The Journal of biological chemistry · 2012Article
- Nitric oxide: considerations for the treatment of ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Effects of nitric oxide on the survival and neuritogenesis of cerebellar Purkinje neurons.Journal of molecular neuroscience : MN · 2012Article
- Multiple embryonic origins of nitric oxide synthase-expressing GABAergic neurons of the neocortex.Frontiers in neural circuits · 2012Article
- Oxidative stress in schizophrenia: an integrated approach.Neuroscience and biobehavioral reviews · 2011Review
- Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD.Free radical biology & medicine · 2009Article
- Nitric oxide alters GABAergic synaptic transmission in cultured hippocampal neurons.Brain research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies have revealed the free radical nitric oxide (NO) to be an important modulator of vascular and neuronal physiology. It also plays a developmental role in regulating synapse formation and patterning. Recent studies suggest that NO may also mediate the switch from proliferation to differentiation during neurogenesis. Many mechanisms of this response are conserved between neuronal precursor cells and the cells of the vascular system, where NO can inhibit the proliferative response of endothelial and smooth-muscle cells to injury. In cultured neuroblastoma cells, NO synthase (NOS) expression is increased in the presence of various growth factors and mitogens. Subsequent production of NO leads to cessation of cell division and the acquisition of a differentiated phenotype. The inhibitory action of NO on neuroblast proliferation has also been demonstrated in vivo for vertebrate and invertebrate nervous systems, as well as in the adult brain. Potential downstream effectors of NO include the second messenger cyclic GMP, activation of the tumor-suppressor genes p53 and Rb, and the cyclin-dependent kinase inhibitor p21. These studies highlight a new role for NO in the nervous system, as a coordinator of proliferation and patterning during neural development and adult neurogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.