ArticleOncogene2003
MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.
Article in Oncogene, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.The Journal of experimental medicine · 2021Article
- MBD1 promotes the malignant behavior of gallbladder cancer cells and induces chemotherapeutic resistance to gemcitabine.Cancer cell international · 2019Article
- The survival analysis and oncogenic effects of CFP1 and 14-3-3 expression on gastric cancer.Cancer cell international · 2019Article
- Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.The Journal of pathology · 2018Article
- Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer.BioMed research international · 2017Article
- Emerging Molecular and Biological Functions of MBD2, a Reader of DNA Methylation.Frontiers in genetics · 2016Review
- LOC100287225, novel long intergenic non-coding RNA, misregulates in colorectal cancer.Cancer biomarkers : section A of Disease markers · 2016Article
- An epigenetic regulator: methyl-CpG-binding domain protein 1 (MBD1).International journal of molecular sciences · 2015Review
- Epigenetics and colorectal cancer pathogenesis.Cancers · 2013Article
- Light-regulated and cell-specific methylation of the maize PEPC promoter.Journal of experimental botany · 2012Article
- Cancer biology and NuRD: a multifaceted chromatin remodelling complex.Nature reviews. Cancer · 2011Review
- The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits.Human molecular genetics · 2008Article
- Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer.Nature clinical practice. Oncology · 2007Review
- Epigenetics provides a new generation of oncogenes and tumour-suppressor genes.British journal of cancer · 2006Review
- Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.Signal transduction and targeted therapyReview
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genes MBD1 and MBD2 encode methyl-CpG binding proteins that suppress transcription from methylated promoters. In contrast, CGBP encodes a protein that binds promoters containing unmethylated CpG and stimulates transcription. All three are located on human chromosome 18q21, a region of frequent loss of heterozygosity in several cancers. These genes therefore represent candidate tumour suppressor genes, whose loss of function could affect the normal regulation of gene expression, whether by lack of complete suppression of genes normally silenced (via loss of MBD1 and MBD2) or by some loss of activation of genes normally expressed (via loss of CGBP), either way contributing to the tumorigenic phenotype. We have confirmed by fluorescent in situ hybridization that MBD1 and MBD2 bracket the DCC locus giving a gene order of MBD1/CGBP-DCC 5'-DCC 3'-MBD2. Mutation analyses by single-stranded conformation polymorphism in colon and lung cancer cell lines and primary tumours revealed a small number of mutations, suggesting only a limited role of these genes in human tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.