Trial reportThorax2003
Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma.
Trial report in Thorax, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01239199 (Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is the Exhaled Nitric Oxide in Infants a Predictive Marker of Asthma?
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 214 citations in OpenAlex.
- Fractional Exhaled Nitric Oxide for the Diagnosis of Childhood Asthma: a Systematic Review and Meta-analysis.Clinical reviews in allergy & immunology · 2019Pooled it
- Atopic characteristics of wheezing children and responses to prednisolone.Pediatric pulmonology · 2007Trial
- Global Research Trends in Forced Oscillation Technique (FOT) and Impulse Oscillometry System (IOS): A Bibliometric Analysis of Impact and Emerging Areas.Healthcare (Basel, Switzerland) · 2026Review
- Predictive Value of Fractional Exhaled Nitric Oxide (FeNO) in the Diagnosis of Asthma for Epidemiological Purposes-An 8-Year Follow-Up Study.Advances in respiratory medicine · 2024Article
- Early Prediction of Asthma.Journal of clinical medicine · 2023Review
- Effects of the salbutamol bronchodilator response on measurements of fractional exhaled nitric oxide in children with asthma: a prospective, observational study.Translational pediatrics · 2022Article
- Clinical significance and applications of oscillometry.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Nitric Oxide Synthase 2 Promoter Polymorphism Is a Risk Factor for Allergic Asthma in Children.Medicina (Kaunas, Lithuania) · 2021Article
- Reduced expiratory variability index (EVI) is associated with controller medication withdrawal and symptoms in wheezy children aged 1-5 years.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020Article
- Relationship between Particulate Matter (PMCanadian respiratory journal · 2020Article
- Article
- The Role of FeNO in Predicting Asthma.Frontiers in pediatrics · 2019Review
- Heart Rate Variability Biofeedback Does Not Substitute for Asthma Steroid Controller Medication.Applied psychophysiology and biofeedback · 2018Article
- Impedance Oscillometry: Emerging Role in the Management of Chronic Respiratory Disease.Current allergy and asthma reports · 2018Review
- Observational
- Accuracy of maximal expiratory flow-volume curve curvilinearity and fractional exhaled nitric oxide for detection of children with atopic asthma.Korean journal of pediatrics · 2017Article
- The case for impulse oscillometry in the management of asthma in children and adults.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2017Review
- An Overview of Fractional Exhaled Nitric Oxide and Children with Asthma.Expert review of clinical immunology · 2016Review
- Monitoring asthma in childhood: lung function, bronchial responsiveness and inflammation.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Diagnostic accuracy of exhaled nitric oxide in asthma: a meta-analysis of 4,691 participants.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory function and airway inflammation can be evaluated in preschool children with special techniques, but their relative power in identifying young children with asthma has not been studied. This study was undertaken to compare the value of exhaled nitric oxide (FE(NO)), baseline lung function, and bronchodilator responsiveness in identifying children with newly detected probable asthma.
methodsNinety six preschool children (age 3.8-7.5 years) with asthmatic symptoms or history and 62 age matched healthy non-atopic controls were studied. FE(NO) was measured with the standard online single exhalation technique, and baseline lung function and bronchodilator responsiveness were measured using impulse oscillometry (IOS).
resultsChildren with probable asthma (n=21), characterised by recent recurrent wheeze, had a significantly higher mean (SE) concentration of FE(NO) than controls (22.1 (3.4) ppb v 5.3 (0.4) ppb; mean difference 16.8 ppb, 95% CI 12.0 to 21.5) and also had higher baseline respiratory resistance, lower reactance, and larger bronchodilator responses expressed as the change in resistance after inhalation of salbutamol. Children with chronic cough only (n=46) also had significantly raised mean FE(NO) (9.2 (1.5) ppb; mean difference 3.9 ppb, 95% CI 0.8 to 7.0) but their lung function was not significantly reduced. Children on inhaled steroids due to previously diagnosed asthma (n=29) differed from the controls only in their baseline lung function. The analysis of receiver operating characteristics (ROC) showed that FE(NO) provided the best power for discriminating between children with probable asthma and healthy controls, with a sensitivity of 86% and specificity of 92% at the cut off level of 1.5 SD above predicted.
conclusionsFE(NO) is superior to baseline respiratory function and bronchodilator responsiveness in identifying preschool children with probable asthma. The results emphasise the presence of airway inflammation in the early stages of asthma, even in young children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.