ArticlePharmacy world & science : PWS2003
Repeated nitrate prescriptions as a potential marker for angina pectoris. A comparison with medical information from the Rotterdam Study.
Article in Pharmacy world & science : PWS, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Risk of myocardial infarction associated with non-steroidal anti-inflammatory drugs: Impact of additional confounding control for variables collected from self-reported data.Journal of clinical pharmacy and therapeutics · 2019Article
- Assessing gaps in cholesterol treatment guidelines for primary prevention of cardiovascular disease based on available randomised clinical trial evidence: The Rotterdam Study.European journal of preventive cardiology · 2018Article
- Identification of major cardiovascular events in patients with diabetes using primary care data.BMC health services research · 2016Article
- Change in prescription pattern as a potential marker for adverse drug reactions of angiotensin converting enzyme inhibitors.International journal of clinical pharmacy · 2015Article
- Use of beta2 agonists and risk of acute myocardial infarction in patients with hypertension.British journal of clinical pharmacology · 2008Article
- Effect of drug combinations on admission for recurrent myocardial infarction.Heart (British Cardiac Society) · 2007Article
- Gender differences in the clinical management of patients with angina pectoris: a cross-sectional survey in primary care.BMC health services research · 2007Article
- Prescribing behaviour according to Dutch and European guidelines on the management of hypercholesterolaemia (1992-1999).British journal of clinical pharmacology · 2006Article
- Drug costs associated with non-adherence to cholesterol management guidelines for primary prevention of cardiovascular disease in an elderly population: the Rotterdam study.Drugs & aging · 2006Article
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Authors and funding
8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to determine whether pharmacy records of nitrate prescriptions could be used as a marker of angina pectoris.
methodThis study was conducted within the Rotterdam Study, a prospective follow-up study which started in 1991 and included 7983 elderly subjects. During follow-up, 1601 subjects filled a first prescription for a nitrate and later filled at least one other prescription for nitrates according to pharmacy records. After excluding subjects who started using nitrates in 1991 and who had less than one year of medication history, we took a random sample of 78 subjects (10%). We studied discharge and outpatient cardiologist letters and files from general practitioners for additional information on angina pectoris in these subjects, and allocated patients to one of three categories according to the possibility of the initial diagnosis of angina being correct.
resultsFrom the random sample of 78, additional information was available on 75 subjects. Definite angina pectoris was present in 33, probable angina pectoris in 18, and possible angina pectoris in 19 subjects. Five subjects had no angina pectoris. Therefore, 93% had at least a possible diagnosis while 68% had at least a probable diagnosis of angina pectoris. The positive predictive value of 2 nitrate prescriptions of which at least one was for rescue therapy was 94%.
conclusionsWe conclude that the use of more than one nitrate prescription can be used as a marker for angina pectoris. This marker may be useful in epidemiological studies.
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