ArticleJournal of perinatology : official journal of the California Perinatal Association2003
Age-related low expression of HLA-DR molecules on monocytes of term and preterm newborns with and without signs of infection.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Myeloid Cell Function and Cytokine Profiles in Paediatric Haemophilia A: Insights From FVIII and Emicizumab Prophylaxis.Journal of cellular and molecular medicine · 2026Article
- Consequences of host-microbiome interactions in preterm infants.Infection and immunity · 2025Review
- Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa.Scientific reports · 2022Article
- Review
- The innate immune response to lower respiratory tract E. Coli infection and the role of the CCL2-CCR2 axis in neonatal mice.Cytokine · 2017Article
- Expression of lymphocyte activation markers of preterm neonates is associated with perinatal complications.BMC immunology · 2016Article
- Identification of a human neonatal immune-metabolic network associated with bacterial infection.Nature communications · 2014Article
- Early sepsis does not increase the risk of late sepsis in very low birth weight neonates.The Journal of pediatrics · 2013Article
- Very low birth weight neonates who survive early-onset sepsis do not have an increased risk of developing late-onset sepsis.Early human development · 2012Article
- Class II MHC antigen presentation defect in neonatal monocytes is not correlated with decreased MHC-II expression.Cellular immunology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPresentation of human leucocyte antigen (HLA) molecules is an important part of an efficient immune response. Since bacterial infections are more common in newborns, we hypothesized that the level of HLA-DR expression may influence the host defense system. STUDY
designHLA-DR expression on monocytes was examined by flow cytometry during the first week of life of term and preterm neonates with and without signs of infection and of adults.
resultsHLA-DR expression of term and preterm newborns with or without signs of infection was lower compared with adults during the first day of life (p<0.0001). Prematurity correlates with lower expression in neonates with gestational age less than 32 weeks (p=0.0008). HLA-DR expression in neonates with signs of infection was decreased compared to healthy neonates (p=0.0196). Maternal conditions such as preeclampsia, prenatal treatment with steroids and mode of delivery had no influence on the expression of HLA-DR. In contrast, newborns with respiratory distress syndrome but without signs of infection showed reduced HLA-DR expression (p=0.0370).
conclusionLow HLA-DR expression on monocytes contributes to impaired neonatal host defense, especially in preterm neonates.
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Registered trials
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