ArticleJournal of perinatology : official journal of the California Perinatal Association2003
Necrotizing enterocolitis among neonates in the United States.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 8 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
154 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Risk factors for necrotizing enterocolitis in preterm infants: a Meta analysis.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Pooled it
- Early full enteral feeding for preterm or low birth weight infants.The Cochrane database of systematic reviews · 2020Pooled it
- Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis.BMC pediatrics · 2020Pooled it
- Slow advancement of enteral feed volumes to prevent necrotising enterocolitis in very low birth weight infants.The Cochrane database of systematic reviews · 2017Pooled it
- Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies.BMC pediatrics · 2017Pooled it
- Antenatal corticosteroids for neonates born before 25 Weeks-A systematic review and meta-analysis.PloS one · 2017Pooled it
- Diagnostic Value of Intestinal Fatty-Acid-Binding Protein in Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis.Indian journal of pediatrics · 2016Pooled it
- Metaanalysis of the effect of antenatal indomethacin on neonatal outcomes.American journal of obstetrics and gynecology · 2007Pooled it
- Effect of Maternal Diet on Any Necrotizing Enterocolitis in Neonates: A Randomized Double-Blind Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2022Trial
- Trial
- Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2013Trial
- Article
- Biofilm state Limosilactobacillus reuteri modulates aryl hydrocarbon receptor activity and suppresses experimental necrotizing enterocolitis.Pediatric research · 2026Article
- Murine intestinal epithelial cells and lymphocytes undergo contrasting inflammatory shifts during gastrointestinal development.Pediatric research · 2026Article
- Risk factors and prediction model for necrotizing enterocolitis in preterm infants with gestational age ≤ 32 weeks: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Preterm infant formulas with glucose polymers and reduced lactose content increase the risk of necrotizing enterocolitis.Frontiers in nutrition · 2026Review
- Application of Umbilical Cord Blood for the Clinical Prevention and Treatment of Complications in Preterm Infants(Review).Stem cell reviews and reports · 2026Review
- The microbiome's hidden influence: preclinical insights into inflammatory responses in necrotizing enterocolitis.Seminars in immunopathology · 2025Review
- Risk Factors and Predictive Parameters of Necrotizing Enterocolitis in Preterm Infants-A Single-Center Retrospective Study.Diseases (Basel, Switzerland) · 2025Article
- Necrotizing Enterocolitis: What's New and What's Next?International journal of molecular sciences · 2025Review
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrior studies have identified individual risk factors that are associated with necrotizing enterocolitis (NEC); however, the small sample sizes of these previous studies have not allowed the analysis of potential interaction between multiple variables and NEC. Our purpose was to describe the incidence and risk factors for NEC in premature neonates admitted for intensive care.
methodsWe identified neonates as having NEC if they met accepted diagnostic criterion for necrotizing enterocolitis. Using a national database, we assessed the association between NEC and a battery of risk factors previously reported in peer-reviewed literature.
resultsThere were 15,072 neonates that met inclusion criteria; 14,682 did not have NEC, while 390 (2.6%) met criterion for NEC. Multivariate analysis showed that low birth weight was the most important risk factor for NEC. Other factors that were associated with an increased risk of NEC were exposure to antenatal glucocorticoids, vaginal delivery, need for mechanical ventilator support, exposure to both glucocorticoids and indomethacin during the first week of life, absence of an umbilical arterial catheter, and low Apgar score at 5 minutes. Length of hospital stay and mortality were higher in neonates with NEC than in neonates without NEC.
conclusionsNEC remains an important cause of morbidity and mortality in prematurely born neonates. In contrast to previous studies, we found that exposure to antenatal glucocorticoids was associated with an increased risk for NEC independent of birth weight.
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