ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Olfactory learning in individually assayed Drosophila larvae.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Finding a path: local search behavior of Drosophila larvae.The Journal of experimental biology · 2025Article
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- Carry-over non-consumptive effects: impact of parasite exposure during larval stage on adult phenotype.Parasitology · 2025Article
- Cognitive limits of larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Alleviation of arsenic-induced neurobehavioral defects with selenium in the larvae of Zaprionus indianus.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Phenylacetaldehyde induced olfactory conditioning in Drosophila melanogaster (Diptera: Drosophilidae) larvae.Journal of insect science (Online) · 2023Article
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Ectoparasitic mites exert non-consumptive effects on the larvae of a fruit fly host.Parasitology · 2023Article
- High-resolution analysis of individualOpen biology · 2023Article
- Mushroom body output neurons MBON-a1/a2 define an odor intensity channel that regulates behavioral odor discrimination learning in larvalFrontiers in physiology · 2023Article
- Review
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- Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery.Frontiers in molecular neuroscience · 2022Review
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- Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine.Biology open · 2021Article
- Octopaminergic neurons have multiple targets inLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Individual Scores for Associative Learning in a Differential Appetitive Olfactory Paradigm Using Binary Logistic Regression Analysis.Frontiers in behavioral neuroscience · 2021Article
- Coupling Transcriptomics and Behaviour to Unveil the Olfactory System of Spodoptera exigua Larvae.Journal of chemical ecology · 2020Article
- Insulin signaling represents a gating mechanism between different memory phases in Drosophila larvae.PLoS genetics · 2020Article
- Identification of Dopaminergic Neurons That Can Both Establish Associative Memory and Acutely Terminate Its Behavioral Expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect and mammalian olfactory systems are strikingly similar. Therefore, Drosophila can be used as a simple model for olfaction and olfactory learning. The brain of adult Drosophila, however, is still complex. We therefore chose to work on the larva with its yet simpler but adult-like olfactory system and provide evidence for olfactory learning in individually assayed Drosophila larvae. We developed a differential conditioning paradigm in which odorants are paired with positive ("+" fructose) or negative ("-" quinine or sodium chloride) gustatory reinforcers. Test performance of individuals from two treatment conditions is compared-one received odorant A with the positive reinforcer and odorant B with a negative reinforcer (A+/B-); animals from the other treatment condition were trained reciprocally (A-/B+). During test, differences in choice between A and B of individuals having undergone either A+/B- or A-/B+ training therefore indicate associative learning. We provide such evidence for both combinations of reinforcers; this was replicable across repetitions, laboratories, and experimenters. We further show that breaks improve performance, in accord with basic principles of associative learning. The present individual assay will facilitate electrophysiological studies, which necessarily use individuals. As such approaches are established for the larval neuromuscular synapse, but not in adults, an individual larval learning paradigm will serve to link behavioral levels of analysis to synaptic physiology.
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