ArticleMolecular and cellular biology2003
Developmentally regulated recruitment of transcription factors and chromatin modification activities to chicken lysozyme cis-regulatory elements in vivo.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
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- A matter of time - How transient transcription factor interactions create dynamic gene regulatory networks.Biochimica et biophysica acta. Gene regulatory mechanisms · 2017Review
- Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.EBioMedicine · 2016Article
- Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.Cell reports · 2014Article
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- Heterochromatin protein 1 gamma and IκB kinase alpha interdependence during tumour necrosis factor gene transcription elongation in activated macrophages.Nucleic acids research · 2012Article
- Transcription of ncDNA: Many roads lead to local gene regulation.Transcription · 2011Article
- Pioneer factors in embryonic stem cells and differentiation.Current opinion in genetics & development · 2010Review
- Interplay between DNA methylation and transcription factor availability: implications for developmental activation of the mouse Myogenin gene.Molecular and cellular biology · 2010Article
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- The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription.Molecular cell · 2008Article
- The Pu.1 locus is differentially regulated at the level of chromatin structure and noncoding transcription by alternate mechanisms at distinct developmental stages of hematopoiesis.Molecular and cellular biology · 2007Article
- A two-step, PU.1-dependent mechanism for developmentally regulated chromatin remodeling and transcription of the c-fms gene.Molecular and cellular biology · 2007Article
- Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of Myb at a physiological target gene.Nucleic acids research · 2007Article
- The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.The EMBO journal · 2006Article
- Developmental activation of the lysozyme gene in chicken macrophage cells is linked to core histone acetylation at its enhancer elements.Nucleic acids research · 2006Article
- Formation of an active tissue-specific chromatin domain initiated by epigenetic marking at the embryonic stem cell stage.Molecular and cellular biology · 2005Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Expression of the chicken lysozyme gene is upregulated during macrophage differentiation and reaches its highest level in bacterial lipopolysaccharide (LPS)-stimulated macrophages. This is accompanied by complex alterations in chromatin structure. We have previously shown that chromatin fine-structure alterations precede the onset of gene expression in macrophage precursor cells and mark the lysozyme chromatin domain for expression later in development. To further examine this phenomenon and to investigate the basis for the differentiation-dependent alterations of lysozyme chromatin, we studied the recruitment of transcription factors to the lysozyme locus in vivo at different stages of myeloid differentiation. Factor recruitment occurred in several steps. First, early-acting transcription factors such as NF1 and Fli-1 bound to a subset of enhancer elements and recruited CREB-binding protein. LPS stimulation led to an additional recruitment of C/EBPbeta and a significant change in enhancer and promoter structure. Transcription factor recruitment was accompanied by specific changes in histone modification within the lysozyme chromatin domain. Interestingly, we present evidence for a transient interaction of transcription factors with lysozyme chromatin in lysozyme-nonexpressing macrophage precursors, which was accompanied by a partial demethylation of CpG sites. This indicates that a partially accessible chromatin structure of lineage-specific genes is a hallmark of hematopoietic progenitor cells.
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